Retinal blood flow in diabetes
Retinal blood flow in diabetes
复制标题
DOI：
10.1080/10739680601072164
复制
发表时间：
2007-01-01
期刊：
影响因子：
2.4
通讯作者：
Bursell, Sven-Erik
中科院分区：
文献类型：
--
作者：
Clermont, Allen C.;Bursell, Sven-Erik
目的：本文综述了糖尿病视网膜血流的特点。该综述描述了视网膜血流测量方法的验证结果，糖尿病啮齿动物模型中视网膜血流异常的各种因素的作用机制，以及将这些结果转化为临床研究，证明不同治疗药物在糖尿病患者视网膜血流异常正常化中的有效性。方法：使用视频荧光素血管造影术进行视网膜血流测量，该方法基于通过视网膜循环测量荧光素染料循环时间。总结了大量实验的结果，详细说明了高血糖的影响以及蛋白激酶C激活、内皮素-1和内皮素-3等因素的作用，血管紧张素II和一氧化氮在糖尿病视网膜血流异常的发展中的作用。视网膜血流量的测量，在动物和临床试验中使用相同的视网膜血流测量方法可以提供有价值的定量方法，其允许表征生理效应及其与糖尿病中的代谢改变的关联以及它们对糖尿病的发展和发病率的影响。微血管并发症
Objective: This is a review of work focused on characterizing retinal blood flow in diabetes. The review describes results on validation of the methodology for retinal blood flow measurements, the mechanisms of action of various of factors that contribute to abnormalities if retinal blood flow in diabetic rodent models, and the translation Of these results to clinical studies demonstrating the effectiveness of different different therapeutic agents in normalizing retinal blood flow abnormalities in patients with diabetes.Methods: Retinal blood flow measurements were performed using video fluorescein angiography, a methodology that is based on the measurement of fluorescein dye circulation times through retinal circulationResults: The results of a number of experiments are summarized, detailing the effects of hyperglycemia and the roles of factors such as Protein kinase C activation, endothelin-1 and endothelin-3, angiotensin- II, and nitric oxide in the development of retinal blood flow abnormalities in diabetes.Conclusion: The measurement of retinal blood flow, both in animals and in clinical trials using the same retinal blood flow measurement methodology can provide a valuable method of quantitation allowing characterization of physiological effects and their association with metabolic alterations in diabetes and their effects on the development and incidence of microvasenlar complications.