Defining the specific physiological requirements for c-Myc in T cell development
Defining the specific physiological requirements for c-Myc in T cell development
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DOI：
10.1038/86308
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发表时间：
2001-04-01
影响因子：
30.5
通讯作者：
Hayday, AC
中科院分区：
文献类型：
--
作者：
Douglas, NC;Jacobs, H;Hayday, AC
c - Myc与许多组织中的细胞生长和细胞周期相关，其表达失调在癌症，特别是淋巴瘤发生中具有因果关系。然而，c - Myc对淋巴细胞发育的作用尚未明确。我们在此表明，c - Myc（-/-）细胞形成正常淋巴细胞存在选择性缺陷。c - Myc（-/-）细胞以年龄依赖的方式在填充胸腺方面效率低下，并且随后的胸腺细胞成熟无效：它们在双阴性（DN）晚期CD4（-）CD8（-）阶段无法正常生长和增殖。由于胸腺细胞中N - Myc的表达通常在DN晚期下降，这些结果证实Myc家族成员对发育的非冗余贡献与其发育基因表达的不同模式有关。
c-Myc is associated with cell growth and cycling in many tissues and its deregulated expression is causally implicated in cancer, particularly lymphomagenesis. However, the contribution of c-Myc to lymphocyte development is unresolved. We show here that the formation of normal lymphocytes by c-Myc(-/-) cells is selectively defective. c-Myc(-/-) cells are inefficient, in an age-dependent manner, at populating the thymus, and subsequent thymocyte maturation is ineffective: they fail to grow and proliferate normally at the late double-negative (DN) CD4(-)CD8(-) stage. Because N-Myc expression in thymocytes usually declines at the late DN stage, these results confirm that the nonredundant contributions of Myc family members to development are related to their distinct patterns of developmental gene expression.