Estrogen treatment during development alters adult partner preference and reproductive behavior in female laboratory rats
Estrogen treatment during development alters adult partner preference and reproductive behavior in female laboratory rats
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DOI：
10.1016/j.yhbeh.2008.08.009
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发表时间：
2009-01-01
影响因子：
3.5
通讯作者：
Clemens, L. G.
中科院分区：
文献类型：
--
作者：
Henley, C. L.;Nunez, A. A.;Clemens, L. G.
人们广泛接受这样一种观点，即在发育过程中雌二醇“组织”生殖行为的许多方面，包括实验室老鼠的伴侣偏好。关于伴侣偏好，这一想法源自研究，在雄性大鼠的发育过程中，通过芳香酶或雌激素受体抑制，雌激素的作用在某种程度上被阻断。新生儿雌激素的缺乏导致雄性大鼠对雌性大鼠的偏好下降。在这项研究中，检查了产后早期雌二醇治疗对雌性大鼠伴侣偏好的影响，作为对男性典型伴侣偏好依赖于早期接触雌激素这一假设的进一步检验。我们的主要发现是，发育过程中产后雌二醇暴露的增加会影响伴侣对预期方向的偏好，并且在几种成人激素和行为测试条件下可以看到这种影响。与接受胆固醇治疗的雌性大鼠相比，在发育过程中接受外源雌二醇的雌性大鼠与发情雌性大鼠相处的时间更长，与性活跃的雄性大鼠相处的时间更少。雌二醇治疗还扰乱了女性正常的性行为、接受能力和受孕能力。由爱思唯尔公司出版
There is broad acceptance for the idea that during development estradiol 'organizes' many aspects of reproductive behavior including partner preferences in the laboratory rat. With respect to partner preference, this idea is drawn from studies where estrogen action was in someway blocked, either through aromatase or estrogen receptor inhibition, during development in male rats. The lack of estrogens neonatally results in a decrease in the male rat's preference for females. In this study, the effect of early postnatal estradiol treatment on the partner preferences of female rats was examined as a further test of the hypothesis that male-typical partner preference is dependent upon early exposure to estrogens. Our principal finding was that increased postnatal estradiol exposure during development affected partner preference in the expected direction, and this effect was seen under several adult hormonal and behavioral testing conditions. Female rats that received exogenous estradiol during development spent more time with an estrous female and less time with a sexually active male than did cholesterol treated females. The estradiol treatment also disrupted normal female sexual behavior, receptivity, and proceptivity. Published by Elsevier Inc.