Neuronal activity in the supplementary motor area of monkeys adapting to a new dynamic environment
Neuronal activity in the supplementary motor area of monkeys adapting to a new dynamic environment
复制标题
DOI：
10.1152/jn.00876.2002
复制
发表时间：
2004-01-01
影响因子：
2.5
通讯作者：
Bizzi, E
中科院分区：
文献类型：
--
作者：
Padoa-Schioppa, C;Li, CSR;Bizzi, E
为了执行视觉引导的伸手动作，中枢神经系统 (CNS) 必须将所需的手部轨迹（运动学）转换为适当的肌肉相关命令（动力学）。有人建议，中枢神经系统可能会通过使用内部动力学前向模型来面对这种具有挑战性的计算。先前对人类的研究发现，新的内部模型可以通过经验获得。在一系列针对猴子的研究中，我们研究了额叶运动区的神经元如何反映运动动态，以及当猴子学习新的内部模型时它们的活动如何变化。在这里，我们描述了辅助运动区（SMA-proper，或 SMA）的结果。在实验中，猴子执行视觉引导的伸手动作并适应外部扰动力场。实验设计允许将与运动动力学相关的神经元活动与与运动运动学相关的神经元活动分开。它还允许将与运动学习相关的变化与与运动性能（运动学和动力学）相关的活动分开。我们表明，SMA 中的神经元反映了个体和群体的运动动态，并且当猴子适应新的动态环境时，它们的活动会经历各种可塑性变化。
To execute visually guided reaching movements, the central nervous system (CNS) must transform a desired hand trajectory (kinematics) into appropriate muscle-related commands (dynamics). It has been suggested that the CNS might face this challenging computation by using internal forward models for the dynamics. Previous work in humans found that new internal models can be acquired through experience. In a series of studies in monkeys, we investigated how neurons in the motor areas of the frontal lobe reflect the movement dynamics and how their activity changes when monkeys learn a new internal model. Here we describe the results for the supplementary motor area (SMA-proper, or SMA). In the experiments, monkeys executed visually guided reaching movements and adapted to an external perturbing force field. The experimental design allowed dissociating the neuronal activity related to movement dynamics from that related to movement kinematics. It also allowed dissociating the changes related to motor learning from the activity related to motor performance (kinematics and dynamics). We show that neurons in SMA reflect the movement dynamics individually and as a population, and that their activity undergoes a variety of plastic changes when monkeys adapt to a new dynamic environment.