Application prospective of nanoprobes with MRI and FI dual-modality imaging on breast cancer stem cells in tumor.
Application prospective of nanoprobes with MRI and FI dual-modality imaging on breast cancer stem cells in tumor.
复制标题
DOI：
10.1186/s12951-016-0195-8
复制
发表时间：
2016-06-23
影响因子：
10.2
通讯作者：
Wang B
中科院分区：
文献类型：
--
作者：
Chen H;Wang Y;Wang T;Shi D;Sun Z;Xia C;Wang B
乳腺癌是一种严重威胁女性生命的疾病。大量研究证明BC来源于肿瘤干细胞(CSC)。但目前还没有一种方法能够快速、简单地鉴定实体瘤中的乳腺癌干细胞。纳米技术很可能能够实现这一目标。但在研究过程中，科学家们发现，似乎只有一种模式的纳米材料，如磁共振成像(MRI)或荧光成像(FI)，都有自己的优点和缺点。不能满足临床实际需要。结合MRI和FI的纳米探针是一种很有前途的工具，可以准确地检测组织中低含量的所需细胞。本文简要介绍了MRI和FI的发展历史，分析了单模纳米材料在肿瘤细胞检测中的优缺点。然后讨论了双模式纳米材料在肿瘤领域的应用进展。最后，为加快纳米探针的临床应用，指出了双模式纳米粒子在BCSCs检测领域存在的障碍和前景。
Breast cancer (BC) is a serious disease to threat lives of women. Numerous studies have proved that BC originates from cancer stem cells (CSCs). But at present, no one approach can quickly and simply identify breast cancer stem cells (BCSCs) in solid tumor. Nanotechnology is probably able to realize this goal. But in study process, scientists find it seems that nanomaterials with one modality, such as magnetic resonance imaging (MRI) or fluorescence imaging (FI), have their own advantages and drawbacks. They cannot meet practical requirements in clinic. The nanoprobe combined MRI with FI modality is a promising tool to accurately detect desired cells with low amount in tissue. In this work, we briefly describe the MRI and FI development history, analyze advantages and disadvantages of nanomaterials with single modality in cancer cell detection. Then the application development of nanomaterials with dual-modality in cancer field is discussed. Finally, the obstacles and prospective of dual-modal nanoparticles in detection field of BCSCs are also pointed out in order to speed up clinical applications of nanoprobes.