NON-OLIGURIC ACUTE RENAL-FAILURE
NON-OLIGURIC ACUTE RENAL-FAILURE
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DOI：
10.1056/nejm197705192962002
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发表时间：
1977-01-01
影响因子：
158.5
通讯作者：
SCHRIER, RW
中科院分区：
文献类型：
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作者：
ANDERSON, RJ;LINAS, SL;SCHRIER, RW
为了描述非少尿性肾衰竭的临床谱，我们对92例急性肾衰竭患者进行了研究，其中54例患者在氮质血症期间均为非少尿性肾衰竭。尽管引起非少尿性肾功能衰竭的原因各不相同，但非少尿性肾功能衰竭的发生率高于少尿性肾功能衰竭（P < 0.01）。与少尿患者相比，无少尿患者的尿钠浓度（P < 0.05）和钠排泄分数（P < 0.02）显著降低，住院时间较短（P < 0.01），脓毒症发作、神经系统异常、胃肠道出血和酸血症发生率较低（P < 0.001），需要透析的次数较少（非少尿患者为26%，少尿患者为50%），死亡率较低（P < 0.05）。非少尿性肾功能衰竭的发生率比一般认识到的要高，发病率和死亡率也比少尿性急性肾功能衰竭低。
To delineate the clinical spectrum of nonoliguric renal failure, 92 patients with acute renal failure, 54 of whom were nonoliguric throughout their periods of azotemia, were studied. Although the causes of nonoliguric renal failure varied, nephrotoxic failure occurred more frequently in nonoliguric than in oliguric subjects (P < 0.01). As compared to oliguric patients, those without oliguria had significantly lower urinary Na concentrations (P < 0.05) and fractional excretions of Na (P < 0.02), had a shorter hospital stay (P < 0.01), had fewer septic episodes, neurologic abnormalities, gastrointestinal bleeding and acidemia, required dialysis less frequently (P < 0.001) and had a lower mortality rate (26% in nonoliguric vs. 50% in oliguric patients-P < 0.05). Nonoliguric renal failure occurs more often than is generally recognized and causes less morbidity and mortality than oliguric acute renal failure.