Effects of excess weight on cancer Incidences depending on cancer sites and histologic findings among men: Korea national health insurance corporation study
Effects of excess weight on cancer Incidences depending on cancer sites and histologic findings among men: Korea national health insurance corporation study
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DOI：
10.1200/jco.2005.11.726
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发表时间：
2005-07-20
影响因子：
45.3
通讯作者：
Shin, SA
中科院分区：
文献类型：
--
作者：
Oh, SW;Yoon, YS;Shin, SA
超重对癌症发展的影响是有争议的，对于美国和欧洲以外的人群知之甚少。我们进行了这项研究，以评估超重的影响与一个大的队列，Koreans.MethodsWe评估了身体质量指数（BMI）和各种癌症之间的关系，在10年的随访队列的781,283名韩国男性谁是免费的先前癌症在基线。测量体重和身高，并完成与健康行为和病史相关的问卷。从韩国的两个组织获得了关于新发癌症的数据。比例风险模型。结果结肠癌、乙状结肠腺癌、肝细胞癌、胆管癌、前列腺癌、肾细胞癌、甲状腺乳头状癌、肺小细胞癌、非霍奇金淋巴瘤、黑色素瘤与BMI呈正剂量依赖关系（P = 30 kg/m2），发生胃腺癌的风险增加（相对风险= 1.73）。其他癌症，如白血病，多发性骨髓瘤，胆囊癌和胰腺癌，没有表现出显着的association.ConclusionThese研究结果表明，即使在韩国人，肥胖明显增加了许多类型的癌症的风险和强度的协会不同的器官和组织学类型。据报道，这些与肥胖有关的癌症在韩国和许多其他亚洲国家迅速增加，因此控制肥胖流行可能是预防这些地区癌症的有效工具。
PurposeThe effects of excess weight on the development of cancers are controversial, and little is known for populations outside the United States and Europe. We conducted this study to assess the effects of excess weight with a large cohort,of Koreans.MethodsWe assessed the relationship between body mass index (BMI) and various cancers in a 10-year follow-up cohort of 781,283 Korean men who were free of prior cancer at baseline. Weight and height were measured, and questionnaires related to health behaviors and medical history were completed. Data on newly developed cancers were obtained from two organizations in Korea. A proportional hazards model. was used to examine the relationship between BMI and cancer.ResultsAdenocarcinoma in the colon and rectosigmoid, hepatocellular carcinoma, cholangiocarcinoma, adenocarcinoma in the prostate, renal cell carcinoma, papillary carcinoma in the thyroid, small-cell carcinoma in the lung, non-Hodgkin's lymphoma, and melanoma had positive dose-dependent relationships with BMI (all P = 30 kg/m(2) had an increased risk of developing gastric adenocarcinoma (relative risk = 1.73). Other cancers, such as leukemia, multiple myeloma, and gallbladder and pancreatic cancer, did not show significant associations.ConclusionThese findings show that, even in Koreans, obesity clearly increases the risk of many types of cancers and the strength of the associations varies with the organ and histologic type. Because these obesity-related cancers are reported to be rapidly increasing in Korea and many other Asian countries, controlling obesity epidemics could be an effective tool for preventing these cancers in these areas.