Redox proteomics screening cellular factors associated with oxidative stress in hepatocarcinogenesis
Redox proteomics screening cellular factors associated with oxidative stress in hepatocarcinogenesis
复制标题
氧化还原蛋白质组学筛选与肝癌发生中氧化应激相关的细胞因子
DOI：
10.1002/prca.201600089
复制
发表时间：
2017-03
影响因子：
2
通讯作者：
Li Qifu
中科院分区：
文献类型：
--
作者：
Zhou Li;Wen Ji;Huang Zhao;Nice Edouard C.;Huang Canhua;Zhang Haiyuan;Li Qifu
肝癌是全球主要的健康问题，是第六大常见癌症和第三大癌症相关死亡原因，其中肝细胞癌占原发性肝癌的90%以上。越来越多的证据表明，与正常的癌细胞相比，许多类型的癌细胞的ROS水平都有所增加。因此，癌细胞需要对抗高水平的ROS，特别是在肿瘤发展的早期阶段。最近的研究表明，ROS介导的氧化还原敏感蛋白(氧化还原感受器)的调节参与了包括癌症在内的许多人类疾病的发病和/或进展。解开氧化还原感受器功能的改变和肝癌发生的潜在机制是开发新的癌症治疗方法的关键。为此，氧化还原蛋白质组学已经发展起来，用于高通量筛选氧化还原传感器，这将有助于开发治疗肝癌的新的治疗策略。在这篇综述中，我们将简要介绍几种新的氧化还原蛋白质组学技术，这些技术目前可用于研究肝癌发生中的各种氧化修饰，并总结与肝癌发生发展相关的氧化还原过程研究中的最重要发现。
Liver cancer is a major global health problem being the sixth most common cancer and the third cause of cancer-related death, with hepatocellular carcinoma (HCC) representing more than 90% of primary liver cancers. Mounting evidence suggests that, compared with their normal counterparts, many types of cancer cell have increased levels of ROS. Therefore, cancer cells need to combat high levels of ROS, especially at early stages of tumor development. Recent studies have revealed that ROS-mediated regulation of redox-sensitive proteins (redox sensors) is involved in the pathogenesis and/or progression of many human diseases, including cancer. Unraveling the altered functions of redox sensors and the underlying mechanisms in.hepatocarcinogenesis is critical for the development of novel cancer therapeutics. For this reason, redox proteomics has been developed for the high-throughput screening of redox sensors, which will benefit the development of novel therapeutic strategies for the treatment of HCC. In this review, we will briefly introduce several novel redox proteomics techniques that are currently available to study various oxidative modifications in hepatocarcinogenesis.and summarize the most important discoveries in the study of redox processes related to the development and progression of HCC.
登录
查看更多内容
影响因子：
81.5
作者：
Llovet, Josep M.;Zucman-Rossi, Jessica;Gores, Gregory
通讯作者：
Gores, Gregory
DOI：
10.1126/science.1211485
发表时间：
2011-12-02
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Anastasiou D;Poulogiannis G;Asara JM;Boxer MB;Jiang JK;Shen M;Bellinger G;Sasaki AT;Locasale JW;Auld DS;Thomas CJ;Vander Heiden MG;Cantley LC
通讯作者：
Cantley LC
影响因子：
25.7
作者：
Dionisio, Natalia;Garcia-Mediavilla, Maria V.;Gonzalez-Gallego, Javier
通讯作者：
Gonzalez-Gallego, Javier
影响因子：
--
作者：
Christopher I Murray;H. S. Chung;H. Uhrigshardt;J. V. Van Eyk
通讯作者：
Christopher I Murray;H. S. Chung;H. Uhrigshardt;J. V. Van Eyk
影响因子：
7
作者：
Murray, Christopher I.;Uhrigshardt, Helge;Van Eyk, Jennifer E.
通讯作者：
Van Eyk, Jennifer E.