The Impact of Communicating Uncertainty on Public Responses to Precision Medicine Research.
The Impact of Communicating Uncertainty on Public Responses to Precision Medicine Research.
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沟通不确定性对公众对精准医学研究反应的影响。
DOI：
10.1093/abm/kaab050
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Kaphingst,KimberlyA
中科院分区：
文献类型：
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作者：
Ratcliff,ChelseaL;Wong,Bob;Jensen,JakobD;Kaphingst,KimberlyA
精准医学研究依赖于招募大量不同的参与者群体来提供遗传、环境和生活方式数据。未来的参与者如何对这项研究的信息做出反应，包括对不确定性的解释，还没有得到很好的理解。PurposeThe当前的研究考察了公众对精准医学研究的反应，重点是对以下两个方面的反应：（a）共享研究数据的科学影响的不确定性，（B）参与者数据的隐私、安全或预期用途的不确定性。成年人（N= 674; 51.9%男性; 50%非西班牙裔白色;法师= 42.23）参与了在线实验调查。参与者阅读了一篇关于精准医学研究的操纵新闻文章，其中传达了每种类型（科学，数据）的确定性或不确定性。然后，参与者评估他们对研究的态度，对研究人员的信任以及加入队列的意愿。我们测试的直接和中介路径之间的消息条件和结果，并检查个人特征作为moderators.ResultsOverall的态度是积极的，大多数参与者（65%）报告说，有点或非常有可能参加精密医学研究，如果邀请。传达任何一种类型的不确定性对结果都没有总体的主要影响。相反，那些认为不确定性更大的人的态度，信任和参与意愿较低，而那些对不确定性更宽容，对科学的支持，和科学的理解积极回应科学的不确定性披露。结论调查结果表明，对精准医学研究的不确定性的反应是微妙的，成功的队列招募可能是很好的-并辅之以与潜在参与者进行沟通的透明方式。
BackgroundPrecision medicine research depends upon recruiting large and diverse participant cohorts to provide genetic, environmental, and lifestyle data. How prospective participants react to information about this research, including depictions of uncertainty, is not well understood.PurposeThe current study examined public responses to precision medicine research, focusing on reactions toward (a) uncertainty about the scientific impact of sharing data for research, and (b) uncertainty about the privacy, security, or intended uses of participant data.MethodsU.S. adults (N= 674; 51.9% male; 50% non-Hispanic white;Mage= 42.23) participated in an online experimental survey. Participants read a manipulated news article about precision medicine research that conveyed either certainty or uncertainty of each type (scientific, data). Participants then rated their attitudes toward the research, trust in the researchers, and willingness to join a cohort. We tested direct and mediated paths between message condition and outcomes and examined individual characteristics as moderators.ResultsOverall attitudes were positive and a majority of participants (65%) reported being somewhat or very likely to participate in precision medicine research if invited. Conveying uncertainty of either type had no overall main effect on outcomes. Instead, those who reported perceiving greater uncertainty had lower attitudes, trust, and willingness to join, while those with more tolerance for uncertainty, support for science, and scientific understanding responded favorably to the scientific uncertainty disclosure.ConclusionsFindings suggest responses to precision medicine research uncertainty are nuanced and that successful cohort enrollment may be well-supported by a transparent approach to communicating with prospective participants.