Dawn of the Epi-LncRNAs: new path from Myheart.
Dawn of the Epi-LncRNAs: new path from Myheart.
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DOI：
10.1161/circresaha.114.305490
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发表时间：
2015-01-16
影响因子：
20.1
通讯作者：
Wang Y
中科院分区：
文献类型：
--
作者：
Wang Z;Wang Y
Myheart是一种心脏特异性长非编码（lnc）RNA，通过与Brg 1直接相互作用靶向调节染色质修饰SWI/SNF复合物。Myheart基因在小鼠心脏中的遗传诱导对心力衰竭的发病机制具有显著的保护作用。LncRNA是新兴的表观遗传调节因子，在心脏发育和疾病中具有潜在的重要作用。
Myheart is a cardiac specific long-noncoding (lnc) RNA with targeted modulation of chromatin modifying SWI/SNF complex via direct interaction with Brg1. Genetic induction of Myheart in mouse heart has a significant protective effect against the pathogenesis of heart failure. LncRNAs are emerging epigenetic regulators with potentially important roles in cardiac development and diseases.