Immunoreactive atrial natriuretic peptide in the retina of rats and rabbits
Immunoreactive atrial natriuretic peptide in the retina of rats and rabbits
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DOI：
10.1016/0006-8993(89)91612-0
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发表时间：
1989-12
期刊：
影响因子：
2.9
通讯作者：
D. Palm;L. Keil;J. Sassani;W. Severs
中科院分区：
文献类型：
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作者：
D. Palm;L. Keil;J. Sassani;W. Severs
免疫反应性心房利钠肽（ANP）已通过放射免疫分析法在视网膜组织中检测到，尽管尚不清楚它是在视网膜细胞中还是代表血液和/或眼液中的残留肽。我们在此报道，使用免疫过氧化物酶方法和高度特异性的抗大鼠ANP，肽一致地定位于大鼠和兔视网膜的外层和内层丛状层。这一信息提出了重要的问题：对视网膜功能的影响是什么？既然血源性放射性配体不显示视网膜“受体”，视网膜ANP的内源性靶标是什么？
Immunoreactive atrial natriuretic peptide (ANP) has been detected in retinal tissue by radioimmunoassay, although it is unclear whether it was in retinal cells or represented residual peptide from blood and/or ocular fluids. We report here, using the immunoperoxidase method and a highly specific anti-rat ANP, that the peptide was localized consitently in the outer and inner plexiform layers of retinas of rats and rabbits. This information raises important issues: what are the implications for retinal function and, since blood-borne radioligands do not reveal retinal ‘receptors’, what is the endogenous target of retinal ANP?