Global defects in collagen secretion in a Mia3/TANGO1 knockout mouse
Global defects in collagen secretion in a Mia3/TANGO1 knockout mouse
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MIA3/Tango1敲除鼠标中胶原蛋白分泌的全局缺陷
DOI：
10.1083/jcb.2010071621942c
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发表时间：
2011-07-25
期刊：
影响因子：
--
通讯作者：
Solloway MJ
中科院分区：
文献类型：
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作者：
Wilson DG;Phamluong K;Li L;Sun M;Cao TC;Liu PS;Modrusan Z;Sandoval WN;Rangell L;Carano RA;Peterson AS;Solloway MJ
分泌细胞中的蛋白质合成受到精细调控，以满足参与生理和发育过程的分泌蛋白质不断变化的需求。具有非凡分泌能力的发育调节细胞的一个例子是发育中骨骼的软骨细胞，其在24小时内从简单的间充质浓缩分化为高度ECM富集的细胞群。蛋白质折叠和转运的效应子必须上调以科普增加的蛋白质负载并支持向高度分泌表型的转变。同时，胶原蛋白和其他ECM蛋白的合成和分泌，包括软骨基质也动态调节骨骼的生长和发育。
Protein synthesis in secretory cells is exquisitely regulated to meet the changing demands for secreted proteins that participate in physiological and developmental processes. One example of developmentally regulated cells with extraordinary secretory capacity are the chondrocytes of the developing skeleton, which differentiate from a simple mesenchymal condensation to a highly ECM-enriched group of cells within 24 h. Effectors of protein folding and transport are necessarily up-regulated to cope with the increased protein load and support the transition to a highly secretory phenotype. Concomitantly, the synthesis and secretion of collagens and other ECM proteins that comprise the cartilage matrix are also dynamically regulated as the skeleton grows and develops.
DOI：
10.1083/jcb.201007162
发表时间：
2011-05-30
期刊：
The Journal of cell biology
影响因子：
--
作者：
Wilson DG;Phamluong K;Li L;Sun M;Cao TC;Liu PS;Modrusan Z;Sandoval WN;Rangell L;Carano RA;Peterson AS;Solloway MJ
通讯作者：
Solloway MJ