Sequential analysis of hepatic carcinogenesis: the comparative architecture of preneoplastic, malignant, prenatal, postnatal and regenerating liver.
Sequential analysis of hepatic carcinogenesis: the comparative architecture of preneoplastic, malignant, prenatal, postnatal and regenerating liver.
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DOI：
10.1038/bjc.1979.261
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发表时间：
1979-11
影响因子：
8.8
通讯作者：
Farber, E
中科院分区：
文献类型：
--
作者：
Ogawa, K;Medline, A;Farber, E
肝细胞增生结节，肝细胞癌的可能的前体，组织模式依次检查在不同阶段的致癌过程中，并与肝细胞癌的模式，在发展中的肝脏和再生的肝脏。扫描以及透射电子显微镜，组织化学与光学显微镜进行了研究。增生病灶内的肝细胞排列成2个或2个以上细胞厚的板状和腺状，与正常成熟肝的1个细胞厚的板状肝细胞不同，并呈不寻常的相互分离，伴不规则扩张的胆小管。增生性病变中发现的组织模式与围产期肝脏发育、细胞分裂高峰后再生肝脏和某些肝细胞癌具有相同的特性。与正常的，其中有一个高度可预测的时间尺度的变化，一个明显的延迟或中断的成熟可能是重要的病变持续存在，并最终演变成肝细胞癌。
The organizational pattern of hepatocytes in hyperplastic nodules, probable precursors of hepatocellular carcinoma, was examined sequentially at different stages in the carcinogenic process, and compared with the patterns in hepatocellular carcinomas, in developing liver and in regnerating liver. Scanning as well as transmission electron microscopy, and histochemistry with light microscopy were used. The hepatocytes in the hyperplastic lesions were arranged in plates 2 or more cells thick and glands, in contrast to the one-cell-thick plates of hepatocytes in normal mature liver, and showed unusualy separation from eachother, with irregularly dilated bile canaliculi. The organizational pattern found in the hyperplastic lesions shared properties with developing liver in the perinatal period, regenerating liver following the peak of cell division, and some hepatocellular carcinomas. Unlike the normal, in which there is a highly predictable time scale for change, an apparent delay or interruption of maturation may be of importance in lesions that persist and ultimately evolve into hepatocullular carcinoma.