Pattern formation in Drosophila head development: the role of the orthodenticle homeobox gene.
Pattern formation in Drosophila head development: the role of the orthodenticle homeobox gene.
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DOI：
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发表时间：
1995-11
期刊：
影响因子：
4.6
通讯作者：
J. Royet;R. Finkelstein
中科院分区：
文献类型：
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作者：
J. Royet;R. Finkelstein
在理解黑腹果蝇成虫盘中的模式形成如何发生方面取得了重大进展，成虫盘形成了果蝇的四肢。在这里，我们研究了眼触角盘中发生的区域规范过程，眼触角盘形成了成年果蝇的头部。我们从遗传学上证明，在形成发育中的头部的特定结构时，正牙齿同源框基因的活性存在分级要求。与此结果一致，我们表明 OTD 蛋白在这些结构的椎间盘原基上以分级方式表达，并且头部特定子结构域的形成需要不同的 OTD 阈值水平。最后，我们提供的证据表明 otd 通过嵌入的节段极性基因发挥作用，以指定内侧头的发育。
Significant progress has been made towards understanding how pattern formation occurs in the imaginal discs that give rise to the limbs of Drosophila melanogaster. Here, we examine the process of regional specification that occurs in the eye-antennal discs, which form the head of the adult fruitfly. We demonstrate genetically that there is a graded requirement for the activity of the orthodenticle homeobox gene in forming specific structures of the developing head. Consistent with this result, we show that OTD protein is expressed in a graded fashion across the disc primordia of these structures and that different threshold levels of OTD are required for the formation of specific subdomains of the head. Finally, we provide evidence suggesting that otd acts through the segment polarity gene engrailed to specify medial head development.