Silver-mediated [3 + 2] cycloaddition of alkynes and N-isocyanoiminotriphenylphosphorane: Access to monosubstituted pyrazoles
Silver-mediated [3 + 2] cycloaddition of alkynes and N-isocyanoiminotriphenylphosphorane: Access to monosubstituted pyrazoles
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银介导的炔烃和 N-异氰基亚氨基三苯基正膦的 [3 2] 环加成：获得单取代的吡唑
DOI：
10.1021/acs.orglett.9b00860
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发表时间：
2019
期刊：
影响因子：
5.2
通讯作者：
Xihe Bi
中科院分区：
文献类型：
--
作者：
Fanhua Yi;Wanjun Zhao;Zikun Wang;Xihe Bi
已经描述了用于构建吡唑的银介导的“CNN”和“C≡C”的[3 + 2]环加成。使用的“CNN”构件是N-异氰基亚氨基三苯基正膦，它是一种稳定、安全、易于处理且无味的固体异氰化物。该反应具有条件温和、底物范围广、官能团耐受性优良等特点。
A silver-mediated [3 + 2] cycloaddition of “CNN” and “C≡C” for constructing pyrazoles has been described. The “CNN” building block used isN-isocyanoiminotriphenylphosphorane, which is a stable, safe, easy-to-handle, and odorless solid isocyanide. The reaction is characterized by its mild conditions, broad substrate scope, and excellent functional group tolerance.