Selective right parietal lobe activation during mental rotation - A parametric PET study
Selective right parietal lobe activation during mental rotation - A parametric PET study
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DOI：
10.1093/brain/123.1.65
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发表时间：
2000-01-01
期刊：
影响因子：
14.5
通讯作者：
Watson, JDG
中科院分区：
文献类型：
--
作者：
Harris, IM;Egan, GF;Watson, JDG
在7名健康受试者进行心理旋转任务的同时，用PET测量了局部脑血流量（rCBF），在该任务中，他们决定以不同方向呈现的字母数字字符是否处于其规范形式或镜像反转。与之前的研究结果一致，当角色从直立位置旋转得更远时，受试者的反应时间相应地更长，这表明他们在做出决定之前在心理上将角色旋转到直立位置。我们使用了一个参数化设计，在这个设计中，我们以递增的方式改变心理旋转的需求，同时保持任务的所有其他方面不变。在四种不同的扫描条件下，10%，40%，70%或100%的刺激在扫描过程中需要心理旋转，而其余的是直立的。统计参数映射技术被用来确定区域的变化，在rCBF与旋转的任务要求。仅在位于右后顶叶的一个区域（Brodmann 7区）中发现了显著的激活，该区域集中在顶内沟上。对猴子和人类的实验文献表明，该区域参与了各种空间转换。我们的研究结果有助于证据表明，这种转换招募心理旋转和添加到一个身体的证据表明，右后顶叶进行视觉空间转换是很重要的。
Regional cerebral blood flow (rCBF) was measured with PET in seven healthy subjects while they carried out a mental rotation task in which they decided whether alphanumeric characters presented in different orientations were in their canonical form or mirror-reversed. Consistent with previous findings, subjects took proportionally longer to respond as characters were rotated further from the upright, indicating that they were mentally rotating the characters to the upright position before making a decision. We used a parametric design in which we varied the mental rotation demands in an incremental fashion while keeping all other aspects of the task constant. In four different scanning conditions, 10, 40, 70 or 100% of the stimuli presented during the scan required mental rotation while the rest were upright. The statistical parametric mapping technique was used to identify areas where changes in rCBF were correlated with the rotational demands of the task. Significant activation was found in only one area located in the right posterior parietal lobe, centred on the intraparietal sulcus (Brodmann area 7), The experimental literature on monkeys and humans suggests that this area is involved in a variety of spatial transformations. Our results contribute evidence that such transformations are recruited during mental rotation and add to a body of evidence which suggests that the right posterior parietal lobe is important for carrying out visuospatial transformations.