Rodent models of anxiety-like behaviors: are they predictive for compounds acting via non-benzodiazepine mechanisms?
Rodent models of anxiety-like behaviors: are they predictive for compounds acting via non-benzodiazepine mechanisms?
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焦虑样行为的啮齿动物模型：它们是否可以预测通过非苯二氮卓机制起作用的化合物？
DOI：
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发表时间：
2001
影响因子：
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通讯作者：
C. Belzung
中科院分区：
文献类型：
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作者：
C. Belzung
对研究最多的临床有效或推测的非苯二氮卓类抗焦虑药在现有的类焦虑行为动物模型中的作用的临床前文献的综述表明，除了5-HT1A激动剂外，这些化合物表现出高度可变的作用。由于这些药物已被证明（选择性5-羟色胺再摄取抑制剂）或建议（CCK(B)和CRF拮抗剂）对焦虑症的治疗活性谱与苯二氮卓类药物不同，苯二氮卓类药物主要用于治疗广泛性焦虑症，因此筛选这些化合物显然需要验证可能模拟这些疾病方面的新技术。
An overview of the preclinical literature on the effects of the most studied clinically effective or putative non-benzodiazepine anxiolytics in existing animal models of anxiety-like behavior indicates that, with the exception of 5-HT1A agonists, these compounds display highly variable effects. Because these drugs have been shown (selective 5-HT reuptake inhibitors) or proposed (CCK(B) and CRF antagonists) to have a different spectrum of therapeutic activity in anxiety disorders than benzodiazepines, agents mainly used against generalized anxiety disorder, the screening of such compounds clearly requires the validation of new techniques that may model aspects of these conditions.