Molecular cardiology in translation: gene, cell and chemical-based experimental therapeutics for the failing heart.
Molecular cardiology in translation: gene, cell and chemical-based experimental therapeutics for the failing heart.
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DOI：
10.1007/s12265-008-9065-6
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发表时间：
2008-12
影响因子：
3.4
通讯作者：
Metzger, Joseph M.
中科院分区：
文献类型：
--
作者：
Turner, Immanuel;Belema-Bedada, Fikru;Martindale, Joshua;Townsend, DeWayne;Wang, Wang;Palpant, Nathan;Yasuda, So-chiro;Barnabei, Matthew;Fomicheva, Ekaterina;Metzger, Joseph M.
获得性和遗传性心脏疾病是该国和全世界的一个主要卫生保健问题。在过去的四分之一个世纪里，临床医学取得了重要的进步，使心脏病患者的几种有效治疗方案成为可能。然而，很明显，即使有最好的护理，目前的治疗策略和疗法也不足以治疗心脏病，这使得它可以说是当今最紧迫的健康问题。在这种情况下，寻求新的方法来纠正衰竭心肌的功能缺陷是很重要的。本文重点介绍了实验室目前正在开发的几种最新的基于基因、细胞和化学物质的实验疗法，以期转化为患者护理。例如，生物传感可诱导基因表达系统的新进展为设计心脏保护蛋白提供了仅在心脏缺氧/缺血期间表达的可能性。干细胞继续提供心脏修复的希望，这里讨论了一些最新的进展。此外，合成聚合物的发现和应用是一种以化学为基础的策略，用于疾病和衰竭心脏组织的急性和慢性治疗。总的来说，这些方法是基础生物医学研究的前线，着眼于将这些发现转化为心脏疾病的临床有意义的应用。
Acquired and inherited diseases of the heart represent a major health care issue in this country and throughout the World. Clinical medicine has made important advancements in the past quarter century to enable several effective treatment regimes for cardiac patients. Nevertheless, it is apparent that even with the best care, current treatment strategies and therapeutics are inadequate for treating heart disease, leaving it arguably the most pressing health issue today. In this context it is important to seek new approaches to redress the functional deficits in failing myocardium. This review focuses on several recent gene, cell and chemical-based experimental therapeutics currently being developed in the laboratory for potential translation to patient care. For example, new advances in bio-sensing inducible gene expression systems offer the potential for designer cardio-protective proteins to be expressed only during hypoxia/ischemia in the heart. Stem cells continue to offer the promise of cardiac repair, and some recent advances are discussed here. In addition, discovery and applications of synthetic polymers are presented as a chemical-based strategy for acute and chronic treatment of diseased and failing cardiac tissue. Collectively, these approaches serve as the front lines in basic biomedical research, with an eye toward translation of these findings to clinically meaningful applications in cardiac disease.
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DOI：
10.1152/ajpheart.00520.2005
发表时间：
2005-11-01
影响因子：
4.8
作者：
Arteaga, GM;Warren, CM;Solaro, RJ
通讯作者：
Solaro, RJ
影响因子：
4.2
作者：
Boast, K;Binley, K;Naylor, S
通讯作者：
Naylor, S
DOI：
10.1073/pnas.2533374100
发表时间：
2003-12-23
影响因子：
11.1
作者：
Erbel, PJA;Card, PB;Gardner, KH
通讯作者：
Gardner, KH
影响因子：
56.9
作者：
Bruick, RK;McKnight, SL
通讯作者：
McKnight, SL
影响因子：
12.4
作者：
Abmayr, S;Gregorevic, P;Chamberlain, JS
通讯作者：
Chamberlain, JS