Stem Cells and Engineered Scaffolds for Regenerative Wound Healing.
Stem Cells and Engineered Scaffolds for Regenerative Wound Healing.
复制标题
DOI：
10.3390/bioengineering5010023
复制
发表时间：
2018-03-09
期刊：
影响因子：
--
通讯作者：
Hsia H
中科院分区：
文献类型：
--
作者：
Dash BC;Xu Z;Lin L;Koo A;Ndon S;Berthiaume F;Dardik A;Hsia H
正常的伤口愈合过程涉及一系列组织良好的生物途径，该过程中的任何失败都会导致伤口变成慢性伤口。无法愈合的伤口是医疗保健系统的负担，并且随着人口老龄化以及肥胖和糖尿病发病率的增加而增加。干细胞疗法具有治愈慢性伤口的潜力，但迄今为止在临床上收效甚微。目前的研究重点是使用聚合物生物材料系统，该系统可以作为这些干细胞的利基，以提高其存活率和旁分泌活性，最终促进伤口愈合。此外，已经开发出不同的修饰策略来提高干细胞的存活和分化，最终促进再生伤口愈合。本综述重点关注先进的聚合物支架，这些支架已用于输送干细胞，并已在临床前伤口动物模型中测试了其效率。
The normal wound healing process involves a well-organized cascade of biological pathways and any failure in this process leads to wounds becoming chronic. Non-healing wounds are a burden on healthcare systems and set to increase with aging population and growing incidences of obesity and diabetes. Stem cell-based therapies have the potential to heal chronic wounds but have so far seen little success in the clinic. Current research has been focused on using polymeric biomaterial systems that can act as a niche for these stem cells to improve their survival and paracrine activity that would eventually promote wound healing. Furthermore, different modification strategies have been developed to improve stem cell survival and differentiation, ultimately promoting regenerative wound healing. This review focuses on advanced polymeric scaffolds that have been used to deliver stem cells and have been tested for their efficiency in preclinical animal models of wounds.