AN EARLY HEMATOPOIETIC DEFECT IN MICE LACKING THE TRANSCRIPTION FACTOR GATA-2
AN EARLY HEMATOPOIETIC DEFECT IN MICE LACKING THE TRANSCRIPTION FACTOR GATA-2
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DOI：
10.1038/371221a0
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发表时间：
1994-09-15
期刊：
影响因子：
64.8
通讯作者：
ORKIN, SH
中科院分区：
文献类型：
--
作者：
TSAI, FY;KELLER, G;ORKIN, SH
血细胞的发育依赖于胚胎中造血干细胞和祖细胞的扩增和维持。通过在小鼠胚胎干细胞中的基因靶向，我们证明了转录因子加塔-2在造血，特别是成人型造血中起着关键作用。我们提出，加塔-2调节基因控制生长因子的反应或早期造血细胞的增殖能力。
Blood cell development relies on the expansion and maintenance of haematopoietic stem and progenitor cells in the embryo. By gene targeting in mouse embryonic stem cells, we demonstrate that the transcription factor GATA-2 plays a critical role in haematopoiesis, particularly of an adult type. We propose that GATA-2 regulates genes controlling growth factor responsiveness or the proliferative capacity of early haematopoietic cells.