HAMSTER EAR MODEL FOR SEBACEOUS GLANDS
HAMSTER EAR MODEL FOR SEBACEOUS GLANDS
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DOI：
10.1111/1523-1747.ep12492637
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发表时间：
1977-01-01
影响因子：
6.5
通讯作者：
LUDERSCHMIDT, C
中科院分区：
文献类型：
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作者：
PLEWIG, G;LUDERSCHMIDT, C
叙利亚仓鼠耳垂的腹侧有丰富的皮脂腺。这些腺体很大，类似于人类的皮脂囊，因为它们有一个漏斗，一个皮脂管，多个小叶和一个从下面进入腺体的毛单位。用平面测量法测定腺体大小，用[3H]-胸腺嘧啶和[3H]-组氨酸放射自显影法测定细胞活性。男性矢状面腺体比女性大得多（0.1750 mm2比0.0727 mm2, P < 0.001），标记指数也更高（19.85%比14.3%,P < 0.01）。注射丙酸睾酮可使雌性仓鼠腺体增大至0.2362 mm2 （P < 0.001）。标注指数也随之增加。腺体总种群的更替期为12 ~ 14天。雄激素敏感性、腺体大小和周转时间使仓鼠耳垂腹面皮脂腺成为合适的研究模型。
The ventral side of the earlobes of Syrian hamsters is richly endowed with sebaceous glands. These glands are large and are similar to human sebaceous follicles since they have an infundibulum, a sebaceous duct, multiple lobules, and a pilary unit which enters from below into the gland. Gland size was measured by planimetry, and cellular activity by autoradiography using [3H]-thymidine and [3H]-histidine. Males have much larger glands in sagittal sections than do females (0.1750 mm2 vs. 0.0727 mm2, P < 0.001) and a higher labeling index (19.85% vs. 14.3%, P < 0.01). Injection of testosterone propionate increases the gland size in female hamsters to 0.2362 mm2 (P < 0.001). The labeling index also increases. The turnover of the total gland population is 12 to 14 days. Androgen sensitivity, gland size, and turnover time make the sebaceous glands on the ventral surface of the hamster earlobe a suitable model for study.