Pd-catalyzed Cross-coupling Reaction of Lithiated Monocarba-closo-dodecaborate at the Carbon Vertex
Pd-catalyzed Cross-coupling Reaction of Lithiated Monocarba-closo-dodecaborate at the Carbon Vertex
复制标题
钯催化碳顶点锂化单碳-近十二硼酸盐的交叉偶联反应
DOI：
10.1055/s-0034-1378833
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发表时间：
2015
期刊：
影响因子：
2
通讯作者：
and Masanobu Uchiyama
中科院分区：
文献类型：
--
作者：
Yu Kitazawa;Mai Otsuka;Junichiro Kanazawa;Ryo Takita;and Masanobu Uchiyama
研究了钯催化下一碳-闭-十二硼酸锂（{[closo-CHB_（11）H_（11）]-}）在碳顶点的交叉偶联反应。金属-碳酸盐络合物在金属转移步骤中的性质对于实现与芳基卤化物的交叉偶联过程是重要的，并且发现使用锂化的单碳-闭合-十二硼酸酯促进碳-碳键的形成以提供一系列C-芳基化的单碳-闭合-十二硼酸酯衍生物。DFT计算的机制研究表明，有效的金属转移与锂试剂。
A cross-coupling reaction of lithium species of monocarba-closo-dodecaborate {[closo-CHB11H11]–} at the carbon vertex under palladium catalysis was developed. The properties of a metal–carborate complex in a transmetalation step were important to achieve the cross-coupling process with aryl halides, and the use of lithiated monocarba-closo-dodecaborate was found to promote the carbon–carbon bond formation to provide a series of C-arylated monocarba-closo-dodecaborate derivatives. Mechanistic investigations with DFT calculations suggested the efficient transmetalation with the lithium reagent.