Diagnostic value of resistin and visfatin, in comparison with C-reactive protein, procalcitonin and interleukin-6 in neonatal sepsis
Diagnostic value of resistin and visfatin, in comparison with C-reactive protein, procalcitonin and interleukin-6 in neonatal sepsis
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DOI：
10.1684/ecn.2011.0283
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发表时间：
2011-06-01
影响因子：
2.8
通讯作者：
Sarici, Serdar Umit
中科院分区：
文献类型：
--
作者：
Cekmez, Ferhat;Canpolat, Fuat Emre;Sarici, Serdar Umit
目的。本研究的目的是评估抵抗素和内脂素在新生儿败血症中的预测价值，并将这些脂肪细胞因子与 C 反应蛋白 (CRP)、降钙素原和白细胞介素 6 (IL-6) 进行比较。捐助者和方法。本研究共纳入 62 名经血培养阳性证实患有败血症的足月或近足月婴儿以及 43 名健康婴儿。结果。两组之间的出生体重和胎龄没有统计学上的显着差异。脓毒症婴儿的白细胞计数（p = 0.039）、CRP水平（p = 0.01）、降钙素原水平（p = 0.01）、IL-6水平（p = 0.01）、内脂素水平（p = 0.01）和抵抗素水平（p = 0.01）显着较高。内脂素、抵抗素与其他标志物（WBC、CRP、降钙素原、IL-6）呈正相关。内脂素的截止值为 10 ng/mL，对新生儿败血症显示出 92% 的敏感性和 94% 的特异性，抵抗素的截止值为 8 ng/mL，显示出 93% 的敏感性和 95% 的特异性。结论。根据这些结果，内脂素和抵抗素可用作新生儿败血症中类似于 CRP、降钙素原和 IL-6 的诊断标志物。需要进一步的研究来更好地了解这些分子在新生儿败血症中的作用和预测价值。
Aim. The aim of this study was to evaluate the predictive value of resistin and visfatin in neonatal sepsis, and to compare these adipocytokines with C-reactive protein (CRP), procalcitonin and interleukin 6 (IL-6). Donors and methods. A total of 62 term or near term infants with sepsis proven by positivity of blood culture, and 43 healthy infants were included in this study. Results. There were no statistically significant differences between the two groups as regards birthweight and gestational age. White blood cell count (p = 0.039), CRP levels (p = 0.01), procalcitonin levels (p = 0.01), IL-6 levels (p = 0.01), visfatin levels (p = 0.01) and resistin levels (p = 0.01) were significantly higher in septic infants. There was a positive correlation between visfatin, resistin and other markers (WBC, CRP, procalcitonin and IL-6). A cut-off value of 10 ng/mL for visfatin, showed 92% sensitivity and 94% specificity, and a cut-off value of 8 ng/mL for resistin showed 93% sensitivity and 95% specificity for neonatal sepsis. Conclusion. In the light of these results, visfatin and resistin can be used as a diagnostic marker similar to CRP, procalcitonin and IL-6 in neonatal sepsis. Further studies are needed to better understand the role and predictive value of these molecules in neonatal sepsis.