Urinary interleukin-18 is a marker of human acute tubular necrosis
Urinary interleukin-18 is a marker of human acute tubular necrosis
复制标题
DOI：
10.1053/j.ajkd.2003.10.040
复制
发表时间：
2004-03-01
影响因子：
13.2
通讯作者：
Edelstein, CL
中科院分区：
文献类型：
--
作者：
Parikh, CR;Jani, A;Edelstein, CL
白细胞介素-18 （IL-18）是小鼠缺血性急性小管坏死（ATN）的介质。方法：测定尿中IL-18是否可作为ATN的标志物。对72例患者进行了研究，包括健康对照组、不同形式的急性肾功能衰竭患者和其他肾脏疾病患者。结果：ATN患者尿IL-18中位浓度显著高于其他所有疾病患者：ATN患者肌酐为644 pg/mg(平均814 +/- 151 [SE] pg/mg肌酐
Background Interleukin-18 (IL-18) is a mediator of ischemic acute tubular necrosis (ATN) in mice. Methods: IL-18 was measured in human urine to determine whether it might serve as a marker of ATN. Seventy-two patients, including healthy controls, patients with different forms of acute renal failure, and patients with other renal diseases, were studied. Results: Patients with ATN had significantly greater median urinary IL-18 concentrations than those with all other conditions: patients with ATN, 644 pg/mg creatinine (mean, 814 +/- 151 [SE] pg/mg creatinine; P