Breast cancer risk and immune responses in healthy women
Breast cancer risk and immune responses in healthy women
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DOI：
10.1188/06.onf.1151-1159
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发表时间：
2006-11-01
影响因子：
1.9
通讯作者：
Kang, Duck-Hee
中科院分区：
文献类型：
--
作者：
Park, Na-Jin;Kang, Duck-Hee
目的/目标：总结客观和主观乳腺癌风险评估的结果及其与有乳腺癌家族史的健康女性的心理困扰和免疫反应的关系。数据来源：已发表的文章和书籍章节。数据综合：有乳腺癌家族史的健康女性表现出免疫反应降低（即，自然杀伤细胞活性低和Th 1细胞因子产生低）、对刺激的生物生理反应过度以及心理压力增加。结论：客观和主观乳腺癌风险与有乳腺癌家族史的健康女性的免疫反应受损和生物生理反应过度相关。心理压力的增加会进一步导致消极的免疫反应。更多的研究是必要的，以证实和扩展的基础上更全面的评估客观和主观的乳腺癌risk.Implications护理的结果：生物生理评估是一个有用的方法，护士在早期识别女性乳腺癌的风险，并制定适当的策略，以减少风险。
Purpose/Objectives: To summarize the findings of objective and subjective breast cancer risk assessments and their association with psychological distress and immune responses in healthy women with a family history of breast cancer.Data Sources: Published articles and book chapters.Data Synthesis: Healthy women with a family history of breast cancer have shown decreased immune responses (i.e., low natural killer cell activity and low Th1 cytokine production), exaggerated biophysiologic reactivity to stimuli, and increased psychological distress.Conclusions: Objective and subjective breast cancer risk is associated with impaired immune responses and exaggerated biophysiologic responses in healthy women with a family history of breast cancer. Increased psychological distress can contribute further to negative immune responses. Additional studies are warranted to substantiate and extend the findings based on more comprehensive assessments of objective and subjective breast cancer risk.Implications for Nursing: Biophysiologic assessment is a useful approach for nurses in early identification of women at risk for breast cancer and developing appropriate strategies to reduce the risk.