Multiplexing using synchrony in the zebrafish olfactory bulb
Multiplexing using synchrony in the zebrafish olfactory bulb
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DOI：
10.1038/nn1292
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发表时间：
2004-08-01
影响因子：
25
通讯作者：
Laurent, G
中科院分区：
文献类型：
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作者：
Friedrich, RW;Habermann, CJ;Laurent, G
在斑马鱼和其他物种的嗅球(OB)中，气味唤起快速振荡的群体活动和跨越二尖瓣细胞(MC)的特定放电模式。这种活动从气味刺激开始，会在几百毫秒内进化。气味特定的MC子集的动作电位对振荡锁相，定义了MC种群输出中的小而分布的集合。我们发现斑马鱼OB中的振荡场势以波的形式在OB中传播。然而，锁相的MC动作电位是同步的，没有时间延迟。用低时间分辨率分析MC的放电率模式可以为气味识别提供信息。当锁相尖峰的灵敏度增加时，活动模式逐渐变得关于气味类别的信息更多。因此，关于互补刺激特征的信息由相同的神经元群体同时传递，并可以通过生物学上看似合理的机制选择性地提取，这表明似乎不同的编码策略可能在不同的时间尺度上共存。
In the olfactory bulb (OB) of zebrafish and other species, odors evoke fast oscillatory population activity and specific firing rate patterns across mitral cells (MCs). This activity evolves over a few hundred milliseconds from the onset of the odor stimulus. Action potentials of odor-specific MC subsets phase-lock to the oscillation, defining small and distributed ensembles within the MC population output. We found that oscillatory field potentials in the zebrafish OB propagate across the OB in waves. Phase-locked MC action potentials, however, were synchronized without a time lag. Firing rate patterns across MCs analyzed with low temporal resolution were informative about odor identity. When the sensitivity for phase-locked spiking was increased, activity patterns became progressively more informative about odor category. Hence, information about complementary stimulus features is conveyed simultaneously by the same population of neurons and can be retrieved selectively by biologically plausible mechanisms, indicating that seemingly alternative coding strategies operating on different time scales may coexist.