Role of serum leptin, insulin, and estrogen levels as potential mediators of the relationship between fat mass and bone mineral density in men versus women
Role of serum leptin, insulin, and estrogen levels as potential mediators of the relationship between fat mass and bone mineral density in men versus women
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DOI：
10.1016/s8756-3282(01)00487-2
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发表时间：
2001-08-01
期刊：
影响因子：
4.1
通讯作者：
Khosla, S
中科院分区：
文献类型：
--
作者：
Thomas, T;Burguera, B;Khosla, S
虽然脂肪量与骨矿物质密度（BMD）有关，但这种影响的潜在机制仍有待确定。因此，我们评估了候选激素，瘦素，胰岛素和雌激素在介导脂肪量对骨骼的影响中的作用。具体来说，我们从一般人群中招募了137名绝经前女性（年龄范围21-54岁）、165名绝经后女性（34-93岁）和343名男性（23-90岁），将这些激素和脂肪量与全髋关节、脊柱中外侧和桡骨中远端的BMD相关联。在绝经前和绝经后的女性中，多个部位的脂肪量和BMD显著相关，而在男性中，这种关系仅在全髋关节处存在。女性血清瘦素水平与骨密度显著相关，而男性血清瘦素水平与骨密度无关。胰岛素与女性髋部BMD相关，生物可利用雌二醇（E-2）与男性和绝经后女性所有部位的BMD相关。在女性中，调整瘦素降低了脂肪量和BMD之间的关联强度，进一步调整胰岛素或生物可利用的E2没有额外的影响。调整瘦素对男性的脂肪量和BMD之间的关系没有一致的影响。总的来说，这些数据表明，脂肪量和瘦素与BMD的关系存在性别二态性，两者均与女性BMD呈正相关，但在男性中则不然。在女性中，瘦素也可能介导脂肪对骨骼的至少部分保护作用。(C)2001年，Elsevier Science Inc. All rights reserved.
Although fat mass is related to bone mineral density (BMD), the potential mechanism(s) of this effect remain to be defined. Thus, we assessed the role of the candidate hormones, leptin, insulin, and estrogen in mediating fat mass effects on the skeleton. Specifically, we related these hormones and fat mass to BMD at the total hip, mid-lateral spine, and middistal radius in a sample of 137 premenopausal women (age range 21-54 years), 165 postmenopausal women (34-93 years), and 343 men (23-90 years) recruited from the general population. Fat mass and BMD were significantly related in pre- and postmenopausal women at multiple sites, whereas this relationship was only weakly present in men at the total hip. Serum leptin levels were also significantly related to BMD in the women, but not in the men. Insulin was associated with hip BMD in the women, and bioavailable estradiol (E-2) was correlated with BMD at all sites in men and in postmenopausal women. In the women, adjusting for leptin reduced the strength of the association between fat mass and BMD, with further adjustments for insulin or bioavailable E2 having no additional effects. Adjusting for leptin in the men had no consistent effect on the relationship between fat mass and BMD. Collectively, these data suggest that there is a sexual dimorphism in the relationship of fat mass and leptin to BMD, with both being positively associated with BMD in women but not in men. In women, leptin may also mediate at least part of the protective effect of fat mass on the skeleton. (C) 2001 by Elsevier Science Inc. All rights reserved.