A mechanochemical model for the steady and transient contractions of the skeletal muscle.
A mechanochemical model for the steady and transient contractions of the skeletal muscle.
复制标题
骨骼肌稳定和瞬时收缩的机械化学模型。
DOI：
10.2170/jjphysiol.26.9
复制
发表时间：
1976
期刊：
影响因子：
--
通讯作者：
H. Mashima
中科院分区：
文献类型：
--
作者：
K. Akazawa;M. Yamamoto;K. Fujii;H. Mashima
提出了一个肌肉收缩的力化学模型，该模型由三个子系统组成：钙离子收缩的调节机制、肌动蛋白-肌球蛋白相互作用的跨桥循环和外加负荷下的收缩动力学。假定跨桥周期的速率常数和跨桥的净力都是滑移速度的线性函数。模型中的大部分参数是由实验数据确定的，但也有几个参数是通过模拟技术估计的。该模型充分描述了肌肉的力-载荷-速度关系、能量和热输出速率以及肌肉的一些基本力学性质。该模型不仅可以解释稳态收缩，还可以解释颤动反应。在数字计算机上用该模型计算等长和等张抽动时的张力和缩短的时间进程。计算曲线与青蛙半腱肌实验曲线吻合较好。等长抽动的张力上升速率与计算的钙浓度曲线几乎同时达到峰值。
A mechanochemical model for muscle contraction was presented which consisted of three subsystems: the regulatory mechanism of contraction by Ca ion, the cross-bridge cycle coupled with actin-myosin interaction and the dynamics of contraction with an external load. It was assumed that both the rate constant of the cross-bridge cycle and the net force of the cross-bridge were linear functions of the sliding velocity. Most parameters in the model were determined from the experimental data, but several were estimated by simulation techniques. The model adequately described the force-load-velocity relation, the rates of energy and heat output as well as some basic mechanical properties of muscle. Not only the steady-state contraction but also the twitch response could be explained by the model. Time courses of tension and shortening during isometric and isotonic twitches were calculated by the model on a digital computer. The calculated curves agreed satisfactorily with the experimental ones obtained from the frog semitendinosus muscle. The rate of tension rise of the isometric twitch was shown to attain the peak at nearly the same time as does the calculated Ca concentration curve.
影响因子：
56.9
作者：
HUXLEY, HE
通讯作者：
HUXLEY, HE