Exploring the Therapeutic Potentials of iNKT Cells for Anti-HBV Treatment.
Exploring the Therapeutic Potentials of iNKT Cells for Anti-HBV Treatment.
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DOI：
10.3390/pathogens3030563
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发表时间：
2014-07-03
期刊：
影响因子：
--
通讯作者：
Yuan W
中科院分区：
文献类型：
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作者：
Lawrenczyk A;Kim S;Wen X;Xiong R;Yuan W
CD 1d限制性不变NKT（iNKT）细胞是一组识别脂质抗原的先天性调节性T细胞。小鼠模型实验和人类临床研究都表明iNKT细胞在抗HBV免疫中的关键作用，这些有效的T细胞可以作为抗HBV治疗的新治疗靶点进行探索。我们的目标是在CD 1d/iNKT细胞脂质呈递系统中人源化小鼠，并为鉴定新型抗HBV药物提供新的研究工具。
CD1d-restricted invariant NKT (iNKT) cells are a group of innate-like regulatory T cells that recognize lipid antigens. Both mouse modeling experiments and human clinical studies have suggested a key role for iNKT cells in anti-HBV immunity and these potent T cells can be explored as a novel therapeutic target for anti-HBV treatment. We aim to humanize mice in the CD1d/iNKT cell lipid presentation system and provide new research tools for identifying novel anti-HBV agents.