Genetics of childhood-onset schizophrenia.
Genetics of childhood-onset schizophrenia.
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DOI：
10.1016/j.chc.2013.06.004
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发表时间：
2013-10
影响因子：
2.4
通讯作者：
Forsyth JK
中科院分区：
文献类型：
--
作者：
Asarnow RF;Forsyth JK
Schizophrenia is a highly heritable disorder. The genetic architecture of schizophrenia is complex and heterogeneous involving both common and rare allelic variants. Given the low prevalence of childhood-onset schizophrenia (COS), relatively few studies have examined the genetic architecture of COS. This review discusses genetic studies of COS and compares findings in familial aggregation, common allele and rare allele studies of COS to those for adult onset schizophrenia (AOS). Overall, the extant literature suggests that COS is a rare variant of AOS with greater familial aggregation of schizophrenia spectrum disorders and a higher occurrence of rare allelic variants. Given the complex genetic architecture of schizophrenia, the utility of genetic screening for diagnosis and individualized treatment is currently limited; however, identifying common pathways through which multiple genes adversely impact neural systems offers great promise towards developing novel pharmacologic interventions.
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影响因子：
10.5
作者：
GOTTESMAN, II;SHIELDS, J
通讯作者：
SHIELDS, J
DOI：
10.1002/ajmg.1701
发表时间：
2002-04-08
期刊：
AMERICAN JOURNAL OF MEDICAL GENETICS
影响因子：
--
作者：
Malaspina, D;Corcoran, C;Gorman, J
通讯作者：
Gorman, J
影响因子：
17.7
作者：
KALLMANN, FJ;ROTH, B
通讯作者：
ROTH, B
影响因子：
3.8
作者：
Duan J;Sanders AR;Gejman PV
通讯作者：
Gejman PV
DOI：
10.1073/pnas.0906232107
发表时间：
2010-04-27
影响因子：
11.1
作者：
Gauthier, Julie;Champagne, Nathalie;Rouleau, Guy A.
通讯作者：
Rouleau, Guy A.