The emerging roles of F-box proteins in pancreatic tumorigenesis.
The emerging roles of F-box proteins in pancreatic tumorigenesis.
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DOI：
10.1016/j.semcancer.2015.09.004
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发表时间：
2016-02
影响因子：
14.5
通讯作者：
Hua Wang;A. Maitra;Huamin Wang
中科院分区：
文献类型：
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作者：
Hua Wang;A. Maitra;Huamin Wang
F-box蛋白在胰腺肿瘤发生中的作用正在显现，这是由于它们在细胞分化、细胞周期调节和增殖中起着关键和不可或缺的作用。本文就β-TrCP（β-transducin repeat-containing protein，β-transducin repeat-containing protein）和Fbxw 7、Fbxw 8两种典型的哺乳动物F-box蛋白在胰腺肿瘤发生、发展中的作用作一综述。我们将重点介绍这些F-box蛋白的功能和调控，它们各自的底物以及与其他关键信号通路的交叉作用，如Ras-Raf-Mek-Erk，Hedgehog，NFκB，TGF-β，Myc和HPK 1信号通路在胰腺癌中的作用。
The role of F-box proteins in pancreatic tumorigenesis is emerging owing to their pivotal and indispensable roles in cell differentiation, cell cycle regulation and proliferation. In this review, we will focus on β-TrCP (β-transducin repeat-containing protein) and two other prototypical mammalian F-box proteins, Fbxw7 and Fbxw8, in pancreatic tumorigenesis and progression. We will highlight the functions and regulation of these F-box proteins, their respective substrates and cross-talks with other key signaling pathways, such as the Ras-Raf-Mek-Erk, Hedgehog, NFκB, TGF-β, Myc and HPK1 signaling pathways in pancreatic cancer.