Direct interaction of Arabidopsis cryptochromes with COP1 in light control development
Direct interaction of Arabidopsis cryptochromes with COP1 in light control development
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DOI：
10.1126/science.1063630
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发表时间：
2001-10-05
期刊：
影响因子：
56.9
通讯作者：
Deng, XW
中科院分区：
文献类型：
--
作者：
Wang, HY;Ma, LG;Deng, XW
拟南芥幼苗光形态发生涉及COP1和HY5两种拮抗成分。COP1在黑暗中通过26S蛋白酶体直接物理相互作用靶向HY5降解。关于光感受器感知的光信号如何调节COP1，我们知之甚少。拟南芥有两个相关的隐色素（cry1和cry2）介导各种蓝色/紫外- a光响应。本研究表明，两种光激活隐色素都通过直接的蛋白质接触抑制COP1活性，这种直接调节是隐色素介导的蓝光对幼苗光形态发育和基因组表达谱的调节的主要原因。
Arabidopsis seedling photomorphogenesis involves two antagonistically acting components, COP1 and HY5. COP1 specifically targets HY5 for degradation via the 26S proteasome in the dark through their direct physical interaction. Little is known regarding how light signals perceived by photoreceptors are transduced to regulate COP1. Arabidopsis has two related cryptochromes (cry1 and cry2) mediating various blue/ultraviolet-A light responses. Here we show that both photoactivated cryptochromes repress COP1 activity through a direct protein-protein contact and that this direct regulation is primarily responsible for the cryptochrome-mediated blue light regulation of seedling photomorphogenic development and genome expression profile.