Quality of life in cystic fibrosis: the impact of gender, general health perceptions and disease severity.
Quality of life in cystic fibrosis: the impact of gender, general health perceptions and disease severity.
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DOI：
10.1016/s1569-1993(03)00093-6
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发表时间：
2003-12-01
期刊：
影响因子：
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通讯作者：
Webb, A K
中科院分区：
文献类型：
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作者：
Gee, L;Abbott, J;Webb, A K
背景：囊性纤维化（CF）的疾病进展以许多生理系统的恶化为标志。此外，有证据表明，女性的预后比男性差。目前的工作评估这两个因素对健康相关的生活质量（HRQoL）的影响：223名青少年和成年人完成了囊性纤维化生活质量（CFQoL）的问卷调查，进一步185接近，不回答不完成的问卷。CFQoL分为九个领域：身体，社会，治疗，胸部症状，情绪功能，对未来的关注，关系，身体形象和职业。客观临床状态的测量包括，体重指数（BMI）和预测的第一秒用力呼气量（FEV 1）的百分比。结果：患者按性别和疾病严重程度细分（轻度> 70%FEV1，中度40-69%和重度< 40%）。析因方差分析显示FEV 1（F = 587.98，P <或= 0.001）和BMI（F = 17.29，P <或= 0.001）作为疾病严重程度的函数具有显著的主效应。事后检验显示，疾病严重程度组之间FEV 1和BMI存在显著的两组差异。在FEV 1或BMI方面没有观察到性别差异。在大多数CFQoL领域中，疾病严重程度存在差异，但对未来的担忧除外，该担忧始终较低。在胸部症状、情绪功能、对未来的担忧、身体形象和职业方面出现了性别差异。除身体形象外，女性的HRQoL较差。Pearson相关性表明，女性的健康感知更密切相关的临床状态比男性。结论：疾病的严重程度有影响HRQoL在青少年和成人CF。男性和女性之间出现了一些差异，女性一般报告较差的HRQoL。有证据表明，男性和女性对自己的健康状况有不同的看法，女性对客观的临床健康状况有更准确的看法。
BACKGROUND: Disease progression in cystic fibrosis (CF) is marked by deterioration across a number of physiological systems. In addition, there is evidence that females have a worse prognosis than males. The current work assesses the impact of both these factors on health related quality of life (HRQoL).METHODS: Two hundred and twenty-three adolescents and adults completed the cystic fibrosis quality of life (CFQoL) questionnaire with a further 185 approached and not responding by non-completion of the questionnaire. The CFQoL is divided into nine domains: physical, social, treatment, chest symptoms, emotional functioning, concerns for the future, relationships, body image, and career. Measurement of objective clinical status included, body mass index (BMI), and percentage of predicted forced expiratory volume in one second (FEV1). General health perceptions (GHP) were also measured.RESULTS: Patients were sub-divided by gender and disease severity (mild > 70% FEV1, moderate 40-69% and severe < 40%). Factorial analysis of variance indicated significant main effects for FEV1 (F = 587.98, P < or = 0.001) and BMI (F = 17.29, P < or = 0.001) as a function of disease severity. Post hoc tests revealed significant two-group differences for FEV1 and BMI between disease severity groups. No differences were observed for gender across FEV1 or BMI. Differences emerged across most CFQoL domains for disease severity, with the exception of concerns for the future, which was consistently low throughout. Gender differences emerged for chest symptoms, emotional functioning, concerns for the future, body image and career. With the exception of body image, females exhibited poorer HRQoL. Pearson correlations indicated that females' perception of health was more closely related to clinical status than males.CONCLUSIONS: Disease severity has an impact on HRQoL in adolescents and adults with CF. Some differences emerged between males and females, with females generally reporting poorer HRQoL. Evidence indicated that males and females perceived their health status differently, with females having a more accurate perception of objective clinical health status.