Variable responses of species and strains to white mineral oils and paraffin waxes.
Variable responses of species and strains to white mineral oils and paraffin waxes.
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物种和菌株对白矿物油和石蜡的不同反应。
DOI：
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发表时间：
1996
期刊：
影响因子：
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通讯作者：
Jason Freeman
中科院分区：
文献类型：
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作者：
Morgan Miller;E. Lonardo;R. D. Greer;C. Bevan;Doug Edwards;J. H. Smith;Jason Freeman
最近对矿物烃（MHC）白色油和蜡的饮食研究表明，Fischer 344（F-344）大鼠具有炎症效应，但在其他大鼠品系或犬中无炎症效应。在F-344大鼠中观察到的组织学效应包括肠系膜淋巴结组织细胞增多症、肝肉芽肿和二尖瓣炎症（仅在石蜡中观察到）。人类摄取MHC可导致组织中的非炎性脂肪肉芽肿（油滴），这在临床上被认为是不重要的。据推测，药代动力学和/或免疫功能的固有种间差异可能导致F-344大鼠对MHC的不同反应。与其他大鼠品系和犬相比，F-344大鼠在靶组织中保留了更大量的MHC，并且似乎比其他物种（包括人类）对MHC更敏感。如对照雌性F-344大鼠中炎性肉芽肿性病变的高背景发生率所示，该品系可能易受这些影响。由于其明显独特的敏感性，在F-344大鼠中观察到的效应与人类健康的相关性值得怀疑，需要进一步研究。
Recent dietary studies on mineral hydrocarbon (MHC) white oils and waxes have shown inflammatory effects in Fischer 344 (F-344) rats, but not in other rat strains or dogs. Histopathologic effects seen in F-344 rats include mesenteric lymph node histiocytosis, liver granulomas, and inflammation of the mitral valve (only seen with paraffin waxes). Human ingestion of MHC can result in noninflammatory lipogranulomas (oil droplets) in tissues which are regarded as clinically unimportant. It is speculated that inherent interspecies differences in pharmacokinetics and/or immune function may contribute to the differential response to MHC seen in F-344 rats. The F-344 rat retains greater amounts of MHC in target tissues compared to other rat strains and dogs and appears to be more sensitive immunologically to MHC than other species, including humans. This strain may be predisposed to these effects as indicated by a high background incidence of inflammatory granulomatous lesions in control female F-344 rats. Because of its apparently unique sensitivity, relevance of effects seen in F-344 rat to human health is questionable and requires further investigation.