Epidemiology of Ulcerative Keratitis in Northern California
Epidemiology of Ulcerative Keratitis in Northern California
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DOI：
10.1001/archophthalmol.2010.144
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发表时间：
2010-08-01
影响因子：
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通讯作者：
Wong, Ira G.
中科院分区：
文献类型：
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作者：
Jeng, Bennie H.;Gritz, David C.;Wong, Ira G.
目的：了解加州北部溃疡性角膜炎的发病率和相关危险因素。方法：在这项大规模的、回顾性的队列研究中，回顾了连续12个月期间所有具有角膜溃疡诊断编码的医疗记录。使用动态人口模型计算发病率。结果：在1093 210例目标人群中，302例患者发生溃疡性角膜炎。溃疡性角膜炎发病率为27.6/10万人年(95%可信区间为24.6~30.9)。角膜溃疡发生率为130.4/10万人年(95%可信区间为111.3~151.7)，调整后相对危险度为9.31(7.42~11.7；P
Objective: To determine the incidence and associated risk factors for ulcerative keratitis in northern California.Methods: In this large-population, retrospective, cohort study, all medical records with diagnosis coding for corneal ulcers during a consecutive 12-month period were reviewed. Incidence rates were calculated using a dynamic population model. Multivariate relative risk regression was conducted to evaluate potential risk factors for ulcerative keratitis.Results: Within the target population of 1 093 210 patients, 302 developed ulcerative keratitis. The incidence of ulcerative keratitis was 27.6 per 100 000 personyears (95% confidence interval, 24.6-30.9). The incidence of corneal ulceration in contact lens wearers was 130.4 per 100 000 person-years (95% confidence interval, 111.3-151.7), with an adjusted relative risk of 9.31 (7.42-11.7; P