A new experimental model in rats for study of the pathophysiology of subarachnoid hemorrhage
A new experimental model in rats for study of the pathophysiology of subarachnoid hemorrhage
复制标题
DOI：
10.1097/00001756-200212200-00034
复制
发表时间：
2002-12-20
期刊：
影响因子：
1.7
通讯作者：
Svendgaard, NA
中科院分区：
文献类型：
--
作者：
Prunell, GF;Mathiesen, T;Svendgaard, NA
本文报道了一种新的大鼠蛛网膜下腔出血(SAH)模型。在交叉前池立体定向置针，手动注血300、250、200 MU，将颅内压控制在平均动脉压(MABP)水平。仅在注射200毫升血液后才观察到可接受的死亡率。在这组患者中，SAH后MABP和颅内压立即升高，但很快接近基线水平。蛛网膜下腔血主要分布在基底池系统，其体积估计约为注入量的95%。这种新的模型与临床SAH相似，重复性好，使用方便，是研究SAH病理生理学的合适模型。
A new experimental model of subarachnoid hemorrhage (SAH) in rats is described. A needle was stereotaxically placed in the pre-chiasmatic cistern and 300, 250 or 200 mul of blood was injected manually, keeping the intracranial pressure (ICP) at the mean arterial blood pressure (MABP) level. An acceptable mortality was observed only after injection of 200 mul of blood. In this group, MABP and ICP increased immediately after SAH, but soon approached baseline levels. The subarachnoid blood was mainly distributed in the basal cisternal system and its estimated volume was about 95% of the amount injected. This new model resembles clinical SAH, is very reproducible, easy to use and seems to be a suitable model for studies of the pathophysiology of SAH.