HOT FLASHES - PHENOMENOLOGY, QUALITY-OF-LIFE, AND SEARCH FOR TREATMENT OPTIONS
HOT FLASHES - PHENOMENOLOGY, QUALITY-OF-LIFE, AND SEARCH FOR TREATMENT OPTIONS
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DOI：
10.1016/0531-5565(94)90012-4
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发表时间：
1994-05-01
影响因子：
3.9
通讯作者：
KRONENBERG, F
中科院分区：
文献类型：
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作者：
KRONENBERG, F
更年期潮热对女性来说是一个严重的问题。潮热会影响日常功能，特别是当它们扰乱睡眠时，导致白天疲劳和烦躁。然而，我们对更年期妇女的这一主诉的了解还远远不够。众所周知，潮热与体温调节、心血管和内分泌变化有关。然而，关于潮热的现象，如潮热的模式和纵向过程的变化范围，还有很多是未知的。虽然雌激素在潮热的病因中起作用，但其停药引发潮热和替代潮热缓解潮热的机制尚不清楚。我们也不知道是什么引发了个体潮热发作。我们开始了解一些因素，比如环境温度，可以调节潮热的频率和严重程度。新的数据表明，摄入某些食物可能会通过食用植物中的雌激素物质影响潮热。虽然有很多关于草药和其他非常规疗法的轶事信息，但很少或根本没有研究评估这些方法治疗潮热的有效性和安全性。立即关注其中一些最有希望的治疗方法可以拓宽现有的治疗选择，并应该为潮热的潜在机制提供新的见解。
Menopausal hot flashes are a significant problem for women. Hot flashes can impact on daily functioning, particularly when they disrupt sleep, leading to fatigue and irritability during the day. However, our knowledge about this primary complaint of menopausal women is far from complete. It is known that a hot flash is associated with thermoregulatory, cardiovascular, and endocrine changes. However, much is unknown about the phenomenology of hot flashes, such as the range of variability in the pattern and longitudinal course of hot flashes. Although estrogen plays a role in the etiology of hot flashes, the mechanism by which its withdrawal precipitates hot flashes and its replacement relieves them is not understood. Nor do we know what it is that triggers individual hot flash episodes. We are beginning to learn about factors, such as ambient temperature, that modulate the frequency or severity of hot flashes. And very, new data suggest that the ingestion of certain foods may influence hot flashes via estrogenic substances present in the food plants. Although there is much anecdotal information about herbs and other nonconventional remedies, little or no research had been done to assess the efficacy or safety of these methods for the treatment of hot flashes. An immediate focus on some of the most promising of these therapies could broaden the available treatment options and should provide new insights into the mechanism underlying hot flashes.