Relationships between serum soluble leptin receptor level and serum leptin and adiponectin levels, insulin resistance index, lipid profile, and leptin receptor gene polymorphisms in the Japanese population
Relationships between serum soluble leptin receptor level and serum leptin and adiponectin levels, insulin resistance index, lipid profile, and leptin receptor gene polymorphisms in the Japanese population
复制标题
DOI：
10.1016/j.metabol.2004.02.009
复制
发表时间：
2004-07-01
影响因子：
9.8
通讯作者：
Saruta, T
中科院分区：
文献类型：
--
作者：
Ogawa, T;Hirose, H;Saruta, T
瘦素在体重调节中起着重要作用，并且已知以游离和结合形式循环。瘦素受体亚型之一以可结合瘦素的循环可溶形式存在。临床研究表明，肥胖个体的可溶性瘦素受体（sOB-R）水平较低。在本研究中，我们测量了419名日本健康受试者（198名男性和221名女性，年龄30至65岁，体重指数[BMI] 21.7 +/- 2.6 [SD] kg/m2）和150名2型糖尿病患者（96名男性和54名女性，BMI 24.3 +/- 3.8 kg/m2）的血清sOB-R水平。研究血清sOB-R水平与BMI、血压、胰岛素抵抗指数（HOMA-IR）、血清瘦素、脂联素水平、血脂谱及瘦素受体（LEPR）基因Lys 109 Arg和Gln 223 Arg多态性的关系。采用放射免疫法（RIA）和酶联免疫吸附法（ELISA）分别测定血清瘦素和sOB-R水平。男性血清sOB-R水平明显高于女性。血清sOB-R水平与BMI、空腹胰岛素、HOMA-IR、血清瘦素水平呈负相关，与高密度脂蛋白胆固醇、血清脂联素水平呈正相关。在健康受试者中，即使校正了年龄、性别和BMI，血清sOB-R水平与空腹胰岛素、HOMA-IR、血清瘦素、脂联素和HDL-胆固醇水平之间的相关性也是显著的。血清sOB-R水平与LEPR基因多态性无相关性。这些结果表明，在日本人群中，血清sOB-R水平与HOMA-IR和血清瘦素水平呈负相关，与HDL-胆固醇水平和血清脂联素水平呈正相关，与年龄、性别和BMI无关。(C)2004爱思唯尔公司All rights reserved.
Leptin plays an important role in the regulation of body weight and is known to circulate in both free and bound forms. One of the leptin receptor isoforms exists in a circulating soluble form that can bind leptin. Clinical studies have shown that soluble leptin receptor (sOB-R) levels are lower in obese individuals. In the present study, we measured the serum sOB-R level in 419 healthy Japanese subjects (198 men and 221 women, aged 30 to 65 years, body mass index [BMI] 21.7 +/- 2.6 [SD] kg/m(2)) and in 150 type 2 diabetic patients (96 men and 54 women, BMI 24.3 +/- 3.8 kg/m(2)). We investigated the relationships between serum sOB-R level and BMI, blood pressure, homeostasis model assessment-insulin resistance index (HOMA-IR), serum leptin and adiponectin levels, lipid profile, and leptin receptor (LEPR) gene Lys109Arg and Gln223Arg polymorphisms. Serum leptin and sOB-R levels were measured by radioimmunoassay (RIA) and enzyme-linked immunosorbent assay (ELISA), respectively. The serum sOB-R level in men was significantly higher than that in women. The serum sOB-R level was negatively correlated with BMI, fasting insulin, HOMA-IR, and serum leptin level and positively correlated with high-density lipoprotein (HDL)cholesterol and serum adiponectin levels. The correlations between serum sOB-R level and fasting insulin, HOMA-IR, serum leptin, adiponectin, and HDL-cholesterol levels were significant even after adjustment for age, sex, and BMI in healthy subjects. There was no association between serum sOB-R level and the LEPR polymorphisms examined. These findings suggest that the serum sOB-R level is negatively correlated with HOMA-IR and serum leptin level and positively correlated with HDL-cholesterol level and serum adiponectin level, independent of age, sex, and BMI, in the Japanese population. (C) 2004 Elsevier Inc. All rights reserved.