Expression and function of trk-C in favourable human neuroblastomas
Expression and function of trk-C in favourable human neuroblastomas
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DOI：
10.1016/s0959-8049(97)00309-2
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发表时间：
1997-10-01
影响因子：
8.4
通讯作者：
Brodeur, GM
中科院分区：
文献类型：
--
作者：
Yamashiro, DJ;Liu, XG;Brodeur, GM
人神经母细胞瘤表达神经营养因子受体trk-A和trk-B。有利的结果与trk-A的表达相关，而不利的是，MYCN扩增的肿瘤表达trk-B。在这项研究中，我们研究了trk-C在原发性神经母细胞瘤肿瘤衍生细胞系中的表达。我们通过北方印迹分析发现，在55例原发性肿瘤中有14例（25%）表达trk-C mRNA。Trk-C在低分期肿瘤（1、2、4S期）中的表达显著高于高分期肿瘤（3、4期，P
Human neuroblastomas express the neurotrophin receptors trk-A and trk-B. Favourable outcome is associated with expression of trk-A, while unfavourable, MYCN amplified tumours express trk-B. In this study we examined the expression of trk-C in primary neuroblastoma tumour-derived cell lines. We found by Northern blot analysis that trk-C mRNA is expressed in 14 of 55 (25%) primary tumours. Trk-C was expressed in significantly more lower stage tumours (stage 1, 2, 4S) than higher stage tumours (stage 3, 4, P