Spatiotemporal patterns of excitation and inhibition evoked by the horizontal network in layer 2/3 of ferret visual cortex.
Spatiotemporal patterns of excitation and inhibition evoked by the horizontal network in layer 2/3 of ferret visual cortex.
复制标题
DOI：
10.1152/jn.00869.2001
复制
发表时间：
2003
影响因子：
2.5
通讯作者：
T. Tucker;L. C. Katz
中科院分区：
文献类型：
--
作者：
T. Tucker;L. C. Katz
视觉皮层第2/3层的水平网络涉及许多心理物理和生理特性。为了研究该网络引起的兴奋和抑制的空间和时间分布，我们使用电压敏感染料成像雪貂视觉皮层2/3层切向切片中对局灶性电刺激的反应。所得到的光学图案包括刺激部位附近的激活扩散区和整个切片中的许多卵形域。与水平连接的固定解剖结构相反，在刺激序列期间，基于群体的神经元活动的分布在空间和时间上的实质性变化是明显的。这两种变化都依赖于抑制性突触电位，表明水平连接驱动的抑制作用塑造了皮层网络中的活动分布。
The horizontal network in visual cortex layer 2/3 is implicated in numerous psychophysical and physiological properties. To investigate the spatial and temporal distribution of excitation and inhibition evoked by this network, we used voltage-sensitive dyes to image the responses to focal electrical stimulation in tangential slices of ferret visual cortex layer 2/3. The resulting optical patterns included a diffuse zone of activation near the stimulation site and numerous ovoid domains throughout the slice. In contrast to the fixed anatomy of the horizontal connections, substantial shifts in both space and time were evident in the distribution of population-based neuronal activity during stimulus trains. Both of these shifts relied on inhibitory synaptic potentials, suggesting that inhibition driven by horizontal connections sculpts the distribution of activity in this cortical network.