Transfer of tissue factor from leukocytes to platelets is mediated by CD15 and tissue factor
Transfer of tissue factor from leukocytes to platelets is mediated by CD15 and tissue factor
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DOI：
10.1182/blood.v96.1.170.013k42_170_175
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发表时间：
2000-07-01
期刊：
影响因子：
20.3
通讯作者：
Nemerson, Y
中科院分区：
文献类型：
--
作者：
Rauch, U;Bonderman, D;Nemerson, Y
我们描述了血栓形成组织因子（TF）的白细胞衍生的微粒和他们纳入自发性人类血栓。多态性白细胞和单核细胞将TF+颗粒转移到血小板，从而使它们能够触发和传播血栓形成。这种现象质疑了血管壁损伤和血管系统内TF暴露于血液足以发生动脉血栓形成的原始教条。TF+白细胞衍生颗粒的转移依赖于CD 15和TF与血小板的相互作用。通过拮抗CD 15与P-选择素的相互作用抑制TF向血小板的转移以及TF本身的直接相互作用都提示了预防血栓形成的新的治疗方法。（血。2000;96：170-175）（C）2000由美国血液学学会。
We describe thrombogenic tissue factor (TF) on leukocyte-derived microparticles and their incorporation into spontaneous human thrombi. Polymorphonuclear leukocytes and monocytes transfer TF+ particles to platelets, thereby making them capable of triggering and propagating thrombosis. This phenomenon calls into question the original dogma that vessel wall injury and exposure of TF within the vasculature to blood is sufficient for the occurrence of arterial thrombosis. The transfer of TF+ leukocyte-derived particles is dependent on the interaction of CD15 and TF with platelets. Both the inhibition of TF transfer to platelets by antagonizing the interaction CD15 with P-selectin and the direct inter action of TF itself suggest a novel therapeutic approach to prevent thrombosis. (Blood. 2000;96:170-175) (C) 2000 by The American Society of Hematology.