A retrospective cohort study estimating the individual Aleutian disease progress in female mink using a VP2 ELISA and its association to reproductive performance
A retrospective cohort study estimating the individual Aleutian disease progress in female mink using a VP2 ELISA and its association to reproductive performance
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DOI：
10.1016/j.prevetmed.2017.02.010
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发表时间：
2017-05-01
影响因子：
2.6
通讯作者：
Wallgren, Per
中科院分区：
文献类型：
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作者：
Andersson, Anna-Maria;Nyman, Ann-Kristin;Wallgren, Per
阿留申病 (AD) 是水貂的一种重要疾病，其特征是持续的慢性感染，通常会导致进行性疾病，症状包括体重减轻、烦渴、多尿、繁殖性能下降和群体死亡率增加等。由于通过消灭AD来根除AD缺乏成功，基于估计疾病进展的疾病控制计划已被实施并用于选择未来的繁殖动物。该项目的目的是评估雌性水貂的繁殖性能（表示为不育或不育以及不育雌性的产仔数）与个体 AD 状态（根据干血斑样本 (DBS) VP2 ELISA 中的 OD450 值定义为患病或未患病）之间的关联，同时控制年龄和颜色类型。该项目包括一项试点研究，其中涉及一个群体中 2067 只雌性水貂的 OD450 值和繁殖性能数据，以及一项后续研究，涉及四个不同群体中 10,368 只初产雌性水貂的数据。为了研究生殖性能与 AD 状态之间的关联，在试点研究中使用了多变量零膨胀泊松回归模型，在后续研究中使用了单变量混合效应 Logistic 和泊松回归模型。在初步研究中，不育与雌性水貂 AD 状态的相互作用与年龄显着相关，初产患病水貂的风险最高，老年非患病水貂的风险最低（OR= 5.8；p
Aleutian Disease (AD) is an important disease in mink characterized by a persistent chronic infection typically causing a progressive disease with symptoms such as weight loss, polydipsia, polyuria, reduced reproductive performance and increased herd mortality. Due to lack of success in eradicating AD by stamping out, disease control programs based on estimating the disease progression have been implemented and used in the selection of future breeding animals. The aim of this project was to evaluate the association between the reproductive performance of female mink (expressed as being barren or not and litter size of non-barren females) and the individual AD status (defined as diseased or non-diseased based on the OD450 value in a dried blood spot samples (DBS) VP2 ELISA) while controlling for age and color type. The project included a pilot study with,data on OD450 values and reproductive performance of 2067 female mink in one herd and a follow-up study with data from 10,368 primiparous female mink in four different herds. To investigate the association between the reproductive performance and the AD status, a multivariable zero-inflated Poisson regression model was used in the pilot study and an univariable mixed-effect logistic and Poisson regression model was used in the follow-up study. In the pilot study, being barren was significantly associated with age in an interaction with the AD status of the female mink with the highest risk among the primiparous diseased mink and lowest risk among older non-diseased mink (OR= 5.8; p