Interactions of retrotransposons with the host genome: the case of the gypsy element of Drosophila.
Interactions of retrotransposons with the host genome: the case of the gypsy element of Drosophila.
复制标题
逆转录转座子与宿主基因组的相互作用：以果蝇吉普赛元素为例。
DOI：
10.1016/0168-9525(91)90277-w
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Geyer,PK
中科院分区：
文献类型：
--
作者：
Corces,VG;Geyer,PK
将吉普赛反转录转座子插入到各种果蝇基因中会导致突变表型，这些表型可以通过各种修饰基因座的第二位点突变来改变。其中一个是毛翼的抑制子，它编码一种DNA结合蛋白，与吉普赛元素的特定序列结合，调节其表达。SU(HW)蛋白和负责突变基因表达的转录因子之间的相互作用是吉普赛人诱导表型的主要原因。吉普赛人似乎也在位于同源染色体上的基因拷贝之间的反式效应中起中介作用。这种染色体间的交流允许位于一条染色体上的转录增强子与位于另一条同源染色体上的目标启动子相互作用。
Insertion of the gypsy retrotransposon into various Drosophila genes results in mutant phenotypes that can be altered by second site mutations in a variety of modifier loci. One of these loci is the suppressor of Hairy-wing, which encodes a DNA-binding protein that binds to specific sequences of the gypsy element to regulate its expression. Interactions between the su(Hw) protein and transcription factors responsible for expression of the mutant genes are the primary cause of gypsy-induced phenotypess. Gypsy also appears to mediate effects in trans between copies of a gene located on homologous chromosomes. This interchromosomal communication allows transcriptional enhancers located in one chromosome to interact with their target promoter located on the other homolog.