Pd(II)-Catalyzed Pyridine N-Oxides Directed Arylation of Unactivated Csp3-H Bonds
Pd(II)-Catalyzed Pyridine N-Oxides Directed Arylation of Unactivated Csp3-H Bonds
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Pd(II) 催化的吡啶 N-氧化物定向未活化 C-sp(3)-H 键的芳基化
DOI：
10.1021/acs.joc.5b00489
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发表时间：
2015-05-01
影响因子：
3.6
通讯作者：
Lu, Xiaoxia
中科院分区：
文献类型：
--
作者：
Liu, Jianzhong;Xie, Ying;Lu, Xiaoxia
开发了一种新型 Pd(II) 催化的二氧化吡啶定向远程芳基化脂肪族酰胺中未活化的 C-sp(3)-H 键与芳基碘化物。该方案允许在烷基羧酸酰胺的 β 或 γ-C-sp(3) 原子上安装各种芳基。通过HR-MS和H-1 NMR方法鉴定了该转化的关键钯双环中间体。
A novel Pd(II)-catalyzed pyridine hi-oxide directed remote arylation of unactivated C-sp(3)-H bonds in aliphatic amides with aryl iodides has been developed. This protocol allows installing various aryl groups at the beta, or gamma-C-sp(3) atom of alkyl carboxylic acid amides. The key palladabicyclic intermediate of this transformation has been identified by HR-MS and H-1 NMR method.