Interstitial lung disease in polymyositis and dermatomyositis
Interstitial lung disease in polymyositis and dermatomyositis
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DOI：
10.1002/art.10794
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发表时间：
2002-12-15
期刊：
影响因子：
--
通讯作者：
Courtois, H
中科院分区：
文献类型：
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作者：
Marie, I;Hachulla, E;Courtois, H
目标.评估多发性肌炎（PM）和皮肌炎（DM）患者间质性肺病（ILD）的患病率、特征和长期预后。确定PM/DM患者ILD病程的预测变量，并确定与PM/DM患者ILD发病相关的临床和生化特征。方法回顾性分析3个医学中心156例PM/DM患者的临床资料。36例PM/DM患者（23.1%）发生ILD。我们观察到19.4%的ILD患者肺部疾病消退，而25%的ILD患者病情恶化。PM/DM合并ILD患者的发病率和死亡率分别高达13.9%和36.4%。与ILD不良结局相关的PM/DM参数确定如下：Hamman-Rich样模式，一氧化碳初始弥散量
Objectives. To assess prevalence, characteristics, and long-term outcome of interstitial lung disease (ILD) in polymyositis (PM) and dermatomyositis (DM). To determine predictive variables of ILD course in PM/DM, and to define both clinical and biochemical features associated with ILD onset in PM/DM.Methods. The medical records of 156 consecutive PM/DM patients in 3 medical centers were reviewed.Results. Thirty-six PM/DM patients (23.1%) developed ILD. We observed that 19.4% of patients with ILD had resolution of pulmonary disorders, whereas 25% experienced ILD deterioration. Morbidity and mortality rates were as high as 13.9% and 36.4%, respectively, in PM/DM patients with ILD. Parameters of PM/DM that related to ILD poor outcome were identified as follows: Hamman-Rich-like pattern, initial diffusing capacity of carbon monoxide