Purine receptors in mammalian tissues: pharmacology and functional significance.
Purine receptors in mammalian tissues: pharmacology and functional significance.
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哺乳动物组织中的嘌呤受体：药理学和功能意义。
DOI：
10.1146/annurev.pa.27.040187.001531
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发表时间：
1987
影响因子：
12.5
通讯作者：
M. Williams
中科院分区：
文献类型：
--
作者：
M. Williams
嘌呤核苷和核苷酸是细胞功能的主要因素。它们是能量途径和细胞代谢过程中的中间体，并且是酶反应 (1) 和细胞复制 (2) 所需的辅因子的组成部分。因此，很难想象这些化学物质也在细胞通讯中发挥作用。用于评估给定化合物是否是神经递质的标准是根据历史先例制定的 (3)。它们基于对原型神经递质乙酰胆碱的了解 (4)。使用此类经典标准，腺苷已被确定为神经调节剂。这一评估降低了人们对嘌呤相关过程作为哺乳动物稳态功能障碍治疗剂靶标的热情。没有证据表明特定的合成代谢过程会形成腺苷，与涉及其一般代谢功能的过程不同。此外，调节核苷细胞外可用性及其分布的生理因素使得神经调节的“嘌呤能”假说的发展变得困难 (5)。由于与腺苷受体相互作用的不同化学实体的缺乏，这些问题变得更加复杂。激动剂几乎都是嘌呤核苷 (6)，而除少数例外，大多数拮抗剂是咪唑并嘧啶 (7-10)。因此，对腺苷受体介导事件的研究是有限的。
Purine nucleosides and nucleotides are major factors in cell function. They are intermediates in energy pathways, in cellular metabolic processes and are constituents of the cofactors necessary for enzymatic reactions (1) and cell replication (2). It has therefore been difficult to visualize that such chemicals also act in cellular communication. The criteria used for evaluating whether a given compound is a neurotransmitter have been developed by historical precedent (3). They are based on knowledge of the prototypic neurotransmitter, acetylcholine (4). Adenosine has been identified as a neuromodulator using such classical criteria. This evaluation has lessened the enthusiasm for purine-related pro cesses as targets for therapeutic agents for malfunctions of mammalian homeostatis. There is no evidence that specific anabolic processes form adenosine, distinct from those involved in its general metabolic functions. Also, the physiological factors regulating the extracellular availability of the nucleoside and its distribution make the development of a "purinergic" hy pothesis of neuromodulation difficult (5). These issues are compounded by the paucity of dissimilar chemical entities that interact with adenosine recep tors. Agonists are almost exclusively purine nucleosides (6), whereas with few exceptions, most antagonists are imidazopyrimidines (7-10). Studies of adenosine receptor-mediated events are thus limited, comparable to in-
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影响因子：
20.3
作者：
MURRAY, JL;LOFTIN, KC;HERSH, EM
通讯作者：
HERSH, EM
培养的主动脉内皮细胞中的花生四烯酸代谢。
影响因子：
5.8
作者：
Whorton,AR;Collawn,JB;Montgomery,ME;Young,SL;Kent,RS
通讯作者：
Kent,RS
腺苷减弱异丙肾上腺素对犬心脏浦肯野纤维的电生理作用。
DOI：
--
发表时间：
1984
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Rardon,DP;Bailey,JC
通讯作者：
Bailey,JC
腺苷在兔肾素释放的致密斑机制中的可能作用。
DOI：
10.1172/jci112118
发表时间：
1985
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Itoh,S;Carretero,OA;Murray,RD
通讯作者：
Murray,RD
2-氯-[3H]-腺苷在离体大鼠肾膜中的结合。
影响因子：
--
作者：
Wu,PH;Churchill,PC
通讯作者：
Churchill,PC