Self-reported depression and anxiety after prenatal famine exposure: mediation by cardio-metabolic pathology?
Self-reported depression and anxiety after prenatal famine exposure: mediation by cardio-metabolic pathology?
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DOI：
10.1017/s2040174411000055
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发表时间：
2011-06-01
影响因子：
1.7
通讯作者：
Roseboom, T. J.
中科院分区：
文献类型：
--
作者：
de Rooij, S. R.;Painter, R. C.;Roseboom, T. J.
先前研究的证据表明，产前暴露于饥荒和增加患抑郁症的风险之间存在关联。本研究的目的是调查产前暴露于荷兰饥荒是否与自我报告的抑郁/焦虑有关，以及这种潜在的关联是否由心脏代谢疾病的存在介导。共有819名在1944-1945年荷兰饥荒期间出生的长期单身人士填写了医院焦虑和抑郁量表（HADS），并被问及他们的病史。作为心脏代谢疾病的指标，我们包括2型糖尿病（T2D）、高血压和冠心病（CHD）。在整个研究人群中，在妊娠早期暴露于饥荒与自我报告的轻度至重度焦虑的存在有关。有证据表明，妊娠早期暴露与性行为之间存在几种相互作用。随后根据性别进行的分析表明，在怀孕早期遭受饥荒的男性在HADS抑郁量表上得分更高。自我报告的轻度至重度焦虑症状在早期暴露的男性中更为普遍。在女性中没有发现这种差异。T2D和高血压与任何抑郁和焦虑指标均无相关性。对冠心病的存在进行调整后，所报道的相关性的减弱程度最低。总之，目前的结果与以前在产前暴露于饥荒的个体中报道的结果不相符。我们发现只有微弱的证据表明产前饥荒暴露与抑郁和焦虑症状之间存在关联，这仅在妊娠早期暴露的男性中表现出来。
Evidence from previous studies suggests an association between prenatal exposure to famine and increased risk for depression. The aim of this study was to investigate whether prenatal exposure to the Dutch famine is associated with self-reported depression/anxiety and whether a potential association is mediated by the presence of cardio-metabolic disease. A total of 819 persons, born as term singletons around the 1944-1945 Dutch famine, filled out the Hospital Anxiety and Depression Scale (HADS) and were asked about their medical history. As indicators of cardiometabolic disease we included type 2 diabetes (T2D), hypertension and coronary heart disease (CHD). In the total study population, exposure to famine during early gestation was associated with the presence of self-reported mild-to-severe anxiety. Evidence was found for several interactions between exposure in early gestation and sex. Subsequent analyses according to sex showed that men exposed to famine during early gestation scored higher on the HADS depression scale. Self-reported mild-to-severe anxiety symptoms were more prevalent among early exposed men. No such differences were found in women. T2D and hypertension were not correlated with any of the depression and anxiety measures. Adjusting for the presence of CHD did minimally attenuate the size of the reported associations. In conclusion, the present results do not match those previously reported in prenatally famine-exposed individuals. We found only weak evidence for an association between prenatal famine exposure and symptoms of depression and anxiety, which was shown exclusively in men exposed during early gestation.