Serum levels of adrenomedullin and inflammatory cytokines in women with term idiopathic intrauterine growth restriction
Serum levels of adrenomedullin and inflammatory cytokines in women with term idiopathic intrauterine growth restriction
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DOI：
10.3109/01443615.2012.721821
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发表时间：
2013-02-01
影响因子：
1.3
通讯作者：
Eldomiaty, M. A.
中科院分区：
文献类型：
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作者：
Elfayomy, A. K.;Habib, F. A.;Eldomiaty, M. A.
本研究旨在探讨足月特发性宫内生长受限(IUGR)孕妇外周血中肾上腺髓质素(AM)、肿瘤坏死因子(TNF)-α和白介素6(IL-6)水平与胎龄(AGA)的关系及其与这些细胞因子的关系。一项病例对照研究包括50名特发性IUGR母亲和25名AGA，评估了她们的血清AM、TNF-α和IL-6水平。发现特发性宫内发育迟缓患者血清AM、肿瘤坏死因子-α和IL-6水平显著高于正常对照组(P分别为0.008、0.016和0.029)，且AM水平与血清肿瘤坏死因子-α水平呈显著正相关(r=0.417，P=0.003)，而与IL-6水平无显著相关。结论：特发性IUGR组AM、TNF-α、IL-6水平显著升高，可能与子宫胎盘血流动力学改变有关，可作为一种有用的生化指标。AM和TNF-α之间的显著相关性可能假设AM和这种炎性细胞因子之间存在复杂的相互作用。
This study aimed to determine the concentrations of adrenomedullin (AM), tumour necrosis factor (TNF)-alpha and interleukin (IL)-6 in maternal circulation of full-term idiopathic intrauterine growth restriction (IUGR) in relation to appropriate-for-gestational-age (AGA) and the possible correlation of AM to these cytokines. A case-control study included 50 idiopathic IUGR mothers and 25 AGA, who were evaluated regarding their serum levels of AM, TNF-alpha and IL-6. We found that women with idiopathic IUGR have significantly higher serum levels of AM, TNF-alpha and IL-6 (p = 0.008; 0.016; 0.029, respectively) and the level of AM was significantly correlated to serum level of TNF-alpha (r = 0.417, p = 0.003) but not significantly correlated to IL-6 compared with the AGA group. In conclusion, the significant increase of AM, TNF-alpha and IL-6 in the idiopathic IUGR group might contribute to the uteroplacental haemodynamic alterations and can serve as a useful biochemical marker. Significant correlation between AM and TNF-alpha could hypothesise the existence of a complex interaction between AM and this inflammatory cytokine.