Further evidence for dementia of the prefrontal type in schizophrenia? A controlled study of teaching the Wisconsin Card Sorting Test.
Further evidence for dementia of the prefrontal type in schizophrenia? A controlled study of teaching the Wisconsin Card Sorting Test.
复制标题
精神分裂症中前额叶型痴呆的进一步证据？
作者：
T. Goldberg;D. Weinberger;K. Berman;N. Pliskin;M. Podd
最近的生理和认知研究表明，前额叶皮层功能障碍可能是精神分裂症智力和社会方面的障碍的一个解释。为了探讨认知缺陷的潜在可逆性和状态变量（如注意力和动机）的作用，对三组精神分裂症患者进行了连续六次的威斯康星州卡片分类测验。其中两组接受了关于如何进行测试的增量信息，包括明确的逐卡指导。第三组作为对照组。不管指导的程度如何，无法完成测试的患者都无法学习，这种缺陷并没有表现出普遍性，因为患者能够在选择性提醒记忆测试中学习单词列表，并且在简易精神状态检查中没有出现全面痴呆。这些数据表明，前额叶型认知功能障碍的精神分裂症可能比一般理解的更深刻。
Recent physiological and cognitive studies of schizophrenia have implicated dysfunction of prefrontal cortex as a possible explanation for some of the disabling intellectual and social aspects of the disorder. To investigate the potential reversibility of cognitive deficits and the role of state variables, eg, attention and motivation, three groups of patients with schizophrenia were administered the Wisconsin Card Sorting Test on six consecutive occasions. Two of the groups received incremental information on how to do the test, including explicit card-by-card instruction. The third group served as a control. Regardless of the degree of instruction, patients who could not do the test could not learn it. The deficit did not appear generalized, as patients were able to learn word lists on the Selective Reminding memory test and were not globally demented on the Mini-Mental State Examination. These data suggest that prefrontal-type cognitive deficits in schizophrenia may be more profound than is generally appreciated.
影响因子：
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作者：
G. Hogarty;C. Anderson;D. Reiss;S. Kornblith;D. Greenwald;C. D. Javna;M. J. Madonia
通讯作者：
G. Hogarty;C. Anderson;D. Reiss;S. Kornblith;D. Greenwald;C. D. Javna;M. J. Madonia