Impact of Type I Interferons on Susceptibility to Bacterial Pathogens.

Impact of Type I Interferons on Susceptibility to Bacterial Pathogens.
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I型干扰素对细菌病原体敏感性的影响

DOI:
10.1016/j.tim.2021.01.007
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发表时间:
2021-09
影响因子:
15.9
通讯作者:
Parker D
Parker D
中科院分区:
生物学1区
文献类型:
--
作者:
Peignier A;Parker D

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干扰素(IFN)是一类具有多方面作用的细胞因子。当涉及到宿主对细菌感染的易感性时,I型IFN具有不同的影响,即结果可能是保护性的,也可能是有害的。到目前为止,已确定的机制是广泛的,不同的病原体之间也不同。在这篇综述中,我们讨论了最近的文献,这些文献从宿主的角度对I型干扰素信号如何影响感染结局的机制提供了新的见解。
Interferons (IFNs) are a broad class of cytokines that have multifaceted roles. Type I IFNs have variable effects when it comes to host susceptibility to bacterial infections, that is, the resulting outcomes can either be protective or deleterious. The mechanisms identified to-date have been wide and varied between pathogens. In this review, we discuss recent literature that provides new insights into the mechanisms of how type I IFN signaling exerts its effects on the outcome to infection from the host’s point of view.
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发表时间: 2014-01
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